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Multi-drug combined rehabilitation granule for type 2 diabetes and application thereof

A technology for type 2 diabetes and granules, which is applied to the multi-drug combination rehabilitation granules for type 2 diabetes and their application fields, can solve the problems of increased drug resistance, negative effects, and degeneration of autologous islet function, and achieves the effect of improving utilization efficiency

Inactive Publication Date: 2017-07-28
杜世睿
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The common problems of these drugs are: 1) With the prolongation of drug use, the dosage will gradually increase; 2) Long-term dependence on external sugar-controlling drugs will also lead to in vivo rejection, increased drug resistance, and gradual degradation of pancreatic islet function; 3) Almost all sugar-controlling drugs have varying degrees of negative effects on internal organs

Method used

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  • Multi-drug combined rehabilitation granule for type 2 diabetes and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] The mass of sorbitol is 35 grams, the mass of Span 60 is 0.1 grams, and the mass of betaine is 8 grams. After uniform mixing, the multi-drug combination rehabilitation granule for type 2 diabetes is obtained;

[0025] Pour the multi-drug combination rehabilitation granule into 500ml water at 80°C and stir until completely dissolved; the solution needs to be drunk within 15-120 minutes.

Embodiment 2

[0027] The mass of sorbitol is 35 grams, the mass of betaine is 10 grams, and the mass of Span 60 is 0.3 grams. After uniform mixing, the multi-drug combination rehabilitation granule for type 2 diabetes is obtained;

[0028] Pour the multi-drug combination rehabilitation granule into 500ml water at 80°C and stir until completely dissolved; the solution needs to be drunk within 15-120 minutes.

Embodiment 3

[0030] The quality of sorbitol is 40 grams, the quality of betaine is 10 grams, and the quality of Span 60 is 0.2 grams. After uniform mixing, the multi-drug combination rehabilitation granule for type 2 diabetes is obtained;

[0031] Pour the multi-drug combination rehabilitation granule into 500ml water at 80°C and stir until completely dissolved; the solution needs to be drunk within 15-120 minutes.

[0032] The type 2 diabetes multi-medicine rehabilitation granule of the present invention may cause diarrhea, abdominal distension, and increased upper and lower exhaust gas after taking it, which can be slowed down or prevented from occurring by prolonging the drug taking time.

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Abstract

The invention discloses a multi-drug combined rehabilitation granule for type 2 diabetes and application thereof. The multi-drug combined rehabilitation granule is formed by compounding of the following components by weight percentage: 45-90% of sorbitol, 5-50% of betaine or betaine hydrochloride, and 0.01-10% of Span-60. The sorbitol involved in the invention enables dissolved fat to form a stable emulsion or ultra microemulsion, with a molecular structure similar to that of glucose molecules, sorbitol can simulate glucose molecules to play a targeted positioning role, also has certain sweetness and can improve the taste of the granule; betaine / betaine hydrochloride is a biosurfactant, can assist dissolution of fat, also has liver protection function, and can improve the insulin utilization efficiency; and Span-60 can gradually dissolve fat deposited on a channel surface. The granule provided by the invention can make fat deposited on the surfaces of channels and semipermeable membranes form a stable "oil-in-water" emulsion or ultra microemulsion, deposited fat can be dissolved and then discharged out of the body through an excretory system, and the utilization efficiency of insulin can be improved.

Description

technical field [0001] The invention relates to a multi-drug combination rehabilitation granule for type 2 diabetes and its application. Background technique [0002] Diabetes is a disease in which insulin secretion in the human body cannot meet the needs of the metabolic system. Type 2 diabetes is caused by people's long-term poor eating habits. There are a wide variety of oral and injectable drugs currently on the market to help diabetics control blood sugar, such as metformin, glucocorticoids, Xiaoke pills, animal insulin and artificial insulin. The common problems of these drugs are: 1) With the prolongation of drug use, the dosage will gradually increase; 2) Long-term dependence on external sugar-controlling drugs will also lead to in vivo rejection, increased drug resistance, and gradual degradation of pancreatic islet function; 3) Almost all sugar-controlling drugs have varying degrees of negative effects on internal organs. [0003] Using chemical theory and resea...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/34A61K31/205A61K31/047A61P3/10
CPCA61K9/0095A61K31/047A61K31/205A61K31/34A61K2300/00
Inventor 曹昌盛杜银龙杜世睿
Owner 杜世睿
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