Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Application of clemastine fumarate in preparation against methicillin-resistant Staphylococcus aureus

A technology of clemastine fumarate and staphylococcus aureus, which is applied in the directions of antibacterial drugs, medical preparations containing active ingredients, pharmaceutical formulas, etc., can solve problems such as toxic side effects, adverse reactions, etc. Development cycle, good clinical response

Active Publication Date: 2021-11-19
MATERNAL & CHILD HEALTH CARE HOSPITAL OF SHANDONG PROVINCE SHANDONG UNIV
View PDF4 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Vancomycin, which has a good curative effect on MRSA infection, has a large number of adverse reactions and side effects when used

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of clemastine fumarate in preparation against methicillin-resistant Staphylococcus aureus
  • Application of clemastine fumarate in preparation against methicillin-resistant Staphylococcus aureus

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] 1. Materials

[0050] 1.1 Drugs and main reagents

[0051] Clemastine fumarate, Meilun Biotechnology Co., Ltd. (Dalian);

[0052] Calcium-adjusted MH Broth Medium (CAMHB), Qingdao High-tech Industrial Park Haibo Biotechnology Co., Ltd. (Qingdao, Shandong);

[0053] MHA agar medium, Qingdao High-tech Industrial Park Haibo Biotechnology Co., Ltd. (Qingdao, Shandong); normal saline, Meilun Biotechnology Co., Ltd. (Dalian);

[0054] 1.2 Experimental strains

[0055] MRSA6 strain isolated and identified by Microbiology Laboratory of Qilu Children's Hospital of Shandong University

[0056] 1.3 Instruments

[0057] Electronic balance (AUY120), SHIMADZU CORPORATION (Japan);

[0058] Bacteria collection ring, Huanyao Pharmaceutical Equipment Sales Co., Ltd. (Beijing, China);

[0059] McFarney Turbidimetric Tube, Kangtai Biotechnology Company (Zhejiang, China);

[0060] Vortex mixer (G-560E), Si company (USA);

[0061] Hot air disinfection box (GRX-9123A), MMM company (Ge...

Embodiment 2

[0076] Example 2 Determination of the dynamic action of clemastine fumarate against MASA

[0077] 1. Materials

[0078] 1.1 Drugs and main reagents

[0079] Clemastine fumarate, Meilun Biotechnology Co., Ltd. (Dalian);

[0080] Calcium-adjusted MH Broth Medium (CAMHB), Qingdao High-tech Industrial Park Haibo Biotechnology Co., Ltd. (Qingdao, Shandong);

[0081] MHA agar medium, Qingdao High-tech Industrial Park Haibo Biotechnology Co., Ltd. (Qingdao, Shandong); normal saline, Meilun Biotechnology Co., Ltd. (Dalian);

[0082] 1.2 Experimental strains

[0083] MASA1 isolated from the microbiology laboratory of Qilu Children's Hospital of Shandong University.

[0084] 1.3 Instruments

[0085] Electronic balance (AUY120), SHIMADZU CORPORATION (Japan);

[0086] Bacteria collection ring, Huanyao Pharmaceutical Equipment Sales Co., Ltd. (Beijing, China);

[0087] McFarney Turbidimetric Tube, Kangtai Biotechnology Company (Zhejiang, China);

[0088] Vortex mixer (G-560E), Si c...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The present invention specifically relates to the application of clemastine fumarate in anti-MRSA preparations. MRSA has high toxicity and is resistant to most common clinical antibiotics, and the strain is widely distributed in the daily environment, so it is a difficult pathogenic strain. In order to develop an active substance that has an inhibitory effect on the above-mentioned drug-resistant bacteria, the present invention screened and verified that clemastine fumarate has a good inhibitory effect on MRSA from clinical drugs, and is expected to be applied to the development of drugs related to anti-MRSA infection.

Description

technical field [0001] The invention belongs to the technical field of antibacterial preparations, and in particular relates to the application of clemastine fumarate in preparation of anti-methicillin-resistant Staphylococcus aureus preparations. Background technique [0002] The information disclosed in this background section is only intended to increase the understanding of the general background of the present invention, and is not necessarily taken as an acknowledgment or any form of suggestion that the information constitutes the prior art already known to those skilled in the art. [0003] In recent years, due to the wide application and irrational use of antibiotics, some common clinical pathogens have developed severe drug resistance, and the level of drug resistance has been increasing, and multi-drug resistant strains have emerged, which has brought great harm to human health. Drug-resistant bacterial infection has become a major challenge in the current medical ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/40A61K45/06A61P31/04
CPCA61K31/40A61K45/06A61P31/04
Inventor 李秀云王艳欣盖中涛郝丽娜张乐海王世富
Owner MATERNAL & CHILD HEALTH CARE HOSPITAL OF SHANDONG PROVINCE SHANDONG UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com