Application of desloratadine in preparation of anti-multidrug-resistant acinetobacter baumannii preparation

A technology of Acinetobacter baumannii and desloratadine, which is applied in the directions of antibacterial drugs, pharmaceutical formulations, medical preparations containing active ingredients, etc., to achieve a good inhibitory effect.

Active Publication Date: 2020-11-13
MATERNAL & CHILD HEALTH CARE HOSPITAL OF SHANDONG PROVINCE SHANDONG UNIV
View PDF0 Cites 3 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the research on desloratadine against

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of desloratadine in preparation of anti-multidrug-resistant acinetobacter baumannii preparation

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0037] Example 1 Determination of static effect of desloratadine against multidrug-resistant Acinetobacter baumannii

[0038] 1. Material

[0039] 1.1 Experimental strains

[0040] 3 strains of Acinetobacter baumannii (AB1, AB2, AB3) isolated from the Microbiology Laboratory of Qilu Children's Hospital of Shandong University and 3 strains of Acinetobacter baumannii (AB11, AB12, AB13) isolated from Qianfoshan Hospital of Shandong Province. It is resistant to antibiotics such as aminoglycosides (gentamicin), carbapenems (meropenem) and quinolones (levofloxacin), all of which are multi-resistant Acinetobacter baumannii.

[0041] 1.2 Drugs and main reagents

[0042] Desloratadine, Shanghai Aladdin Biochemical Technology Co., Ltd. (Shanghai);

[0043] Calcium-regulated MH Broth Medium (CAMHB), Qingdao Hi-Tech Industrial Park Haibo Biotechnology Co., Ltd. (Qingdao, Shandong);

[0044] MHA agar medium, Qingdao Hi-Tech Industrial Park Haibo Biotechnology Co., Ltd. (Qingdao, Shandong);

[0045] No...

Example Embodiment

[0068] Example 2 Determination of the dynamic effect of desloratadine against multidrug-resistant Acinetobacter baumannii

[0069] 1. Material

[0070] 1.1 Drugs and main reagents

[0071] Desloratadine, Shanghai Aladdin Biochemical Technology Co., Ltd. (Shanghai);

[0072] Calcium-regulated MH Broth Medium (CAMHB), Qingdao Hi-Tech Industrial Park Haibo Biotechnology Co., Ltd. (Qingdao, Shandong);

[0073] MHA agar medium, Qingdao Hi-Tech Industrial Park Haibo Biotechnology Co., Ltd. (Qingdao, Shandong);

[0074] Normal saline, Shanghai Aladdin Biochemical Technology Co., Ltd. (Shanghai);

[0075] 1.2 Experimental strains

[0076] Multi-drug resistant Acinetobacter Baumannii strain AB11 isolated from Qianfoshan Hospital in Shandong Province.

[0077] 1.3 Instrument

[0078] Electronic balance (AUY120), SHIMADZU CORPORATION (Japan);

[0079] Take the bacteria ring, Huanyao Pharmaceutical Equipment Sales Co., Ltd. (Beijing, China);

[0080] Maxwell Turbidity Tube, Kangtai Biotechnology Company (...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention provides an application of desloratadine in preparation of an anti-multidrug resistant acinetobacter baumannii preparation. Acinetobacter baumannii is a conditioned pathogenic bacteriumwith extremely strong vitality, and is a common pathogenic bacterium for hospital infection. Acinetobacter baumannii has innate drug resistance to common antibiotics, and drug resistance is easy to generate. The invention aims to provide an active substance with a prospect for developing multi-drug-resistant acinetobacter baumannii treatment drugs, and according to the research result of the invention, desloratadine has a good inhibition effect on multi-drug-resistant acinetobacter baumannii, and is expected to be used as the active substance to be applied to the development of related antibacterial drugs.

Description

technical field [0001] The invention belongs to the technical field of antimicrobial drugs, and in particular relates to the application of desloratadine in preparing anti-multidrug-resistant Acinetobacter baumannii preparations. Background technique [0002] The information disclosed in this background section is only intended to increase the understanding of the general background of the present invention, and is not necessarily taken as an acknowledgment or any form of suggestion that the information constitutes the prior art already known to those skilled in the art. [0003] Acinetobacter baumannii has become one of the most difficult pathogens for global health institutions. Due to the innate resistance of Acinetobacter baumannii to some commonly used antibiotics, coupled with the large number and widespread use of broad-spectrum antibiotics, it is difficult to The drug resistance is gradually increasing, and the strains of multidrug-resistant Acinetobacter baumannii (...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K31/4545A61K45/06A61P31/04
CPCA61K31/4545A61K45/06A61P31/04A61K2300/00
Inventor 李秀云王艳欣盖中涛王世富张乐海
Owner MATERNAL & CHILD HEALTH CARE HOSPITAL OF SHANDONG PROVINCE SHANDONG UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap