Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Rehmannia glutinosa polysaccharide/xenogeneic calcined allo-bone composite bone repair material

A technology of rehmannia polysaccharide and calcined bone, which is applied in medical science, tissue regeneration, prosthesis, etc., can solve the problems of insufficient osteoinductive activity, achieve excellent osteogenesis effect, key technology control, and promote bone formation

Active Publication Date: 2020-11-13
FIRST AFFILIATED HOSPITAL OF DALIAN MEDICAL UNIV
View PDF10 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Therefore, the embodiment of the present invention provides a rehmannia polysaccharide / heterogeneous calcined bone composite bone repair material. Calcined bone composite can effectively solve the problem of insufficient osteoinductive activity in existing heterogeneous calcined bones

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Rehmannia glutinosa polysaccharide/xenogeneic calcined allo-bone composite bone repair material
  • Rehmannia glutinosa polysaccharide/xenogeneic calcined allo-bone composite bone repair material
  • Rehmannia glutinosa polysaccharide/xenogeneic calcined allo-bone composite bone repair material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] The rehmannia polysaccharide / heterogeneous calcined bone composite bone repair material of this embodiment:

[0029] 1. Preparation of heterogeneous calcined bone scaffold materials

[0030] The bilateral femurs of adult cattle were taken, and the cancellous bone part of the femoral epiphysis was sawed off, and other tissues attached to the bone were peeled off, and then cut into 4×4×4mm bone pieces with a cutting machine and washed; the washed The final bone was soaked in 0.5mol / L NaOH solution for 1 h, ultrasonically cleaned with purified water for 3 times, each time for 8 min, and then the bone was immersed in 3% H 2 o 2 Solution for 20 minutes, ultrasonic cleaning with purified water for 3 times, each time for 8 minutes; put the treated bone into boiling water, boil for 1 hour to remove part of the protein and lipid, dry the bone overnight after cooling, put the dried bone Put it into a muffle furnace for calcination, control the temperature and slowly raise the t...

Embodiment 2

[0038] The rehmannia polysaccharide / heterogeneous calcined bone composite bone repair material of this embodiment:

[0039] 1. Preparation of heterogeneous calcined bone scaffold materials

[0040] The bilateral femurs of adult cattle were taken, and the cancellous bone part of the epiphysis of the femur was sawed off, and other tissues attached to the bone were peeled off, and then cut into 5×5×5mm bone pieces with a cutting machine and washed; the washed The final bone was soaked in 0.5mol / L NaOH solution for 3h, ultrasonically cleaned with purified water for 3 times, each time for 10min, and then the bone was immersed in 3% H 2 o 2 Solution for 25 minutes, ultrasonic cleaning with purified water for 3 times, each time for 10 minutes; put the treated bone into boiling water, boil for 1.5 hours to remove part of the protein and lipid, after the bone is cooled, dry overnight, and dry the bone Put it into a muffle furnace for calcination, control the temperature and slowly in...

Embodiment 3

[0048] The rehmannia polysaccharide / heterogeneous calcined bone composite bone repair material of this embodiment:

[0049] 1. Preparation of heterogeneous calcined bone scaffold materials

[0050] The bilateral femurs of adult cattle were taken, and the cancellous bone part of the femoral epiphysis was sawed off, and other tissues attached to the bone were peeled off, and then cut into 6×6×6mm bone pieces with a cutting machine and washed; the washed The final bone block was soaked in 0.5mol / L NaOH solution for 3h, ultrasonically cleaned with purified water for 3 times, each time for 15min, and then the bone block was immersed in 3% H 2 o 2 solution for 45 minutes, ultrasonically cleaned with purified water for 3 times, each time for 15 minutes; put the treated bone into boiling water, boil for 2 hours to remove part of the protein and lipid, dry the bone overnight after cooling, put the dried bone in Put it into a muffle furnace for calcination, control the temperature and...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Particle sizeaaaaaaaaaa
Particle sizeaaaaaaaaaa
Login to View More

Abstract

The embodiment of the invention discloses a rehmannia glutinosa polysaccharide / xenogeneic calcined allo-bone composite bone repair material, and belongs to the technical field of medical materials. The material is formed by compounding a calcined allo-bone scaffold material and a rehmannia glutinosa polysaccharide solution. The rehmannia glutinosa polysaccharide disclosed by the invention has an excellent osteogenesis promoting effect, and after the rehmannia glutinosa polysaccharide is compounded with the calcined allo-bone scaffold material, the bone induction activity of calcined allo-bonecan be enhanced on the premise of not influencing the cell activity, so that the aims of promoting bone formation and repairing bone defects are achieved. The bone repair material provided by the invention has bone growth promoting activity and bone defect repair activity close to those of an autologous bone, the production process is simple to operate, the key technology is easy to control, the production cost is relatively low, and a better bone repair scheme is provided for clinic.

Description

technical field [0001] The embodiments of the present invention relate to the technical field of medical materials, in particular to a rehmannia polysaccharide / heterogeneous calcined bone composite bone repair material. Background technique [0002] Clinically, large bone defects are common due to various reasons such as high-energy trauma, bone tumor resection, etc., and usually cannot heal on their own, which is a thorny problem to be solved urgently in clinical practice. Autologous bone grafting has become the gold standard for bone defect repair due to its excellent osteoinductive, osteoconductive, and osteogenic capabilities, as well as non-immunogenicity, non-cytotoxicity, and good histocompatibility, but there is pain in the donor site of autologous bone. And local complications such as hematoma, fracture, infection, and the potential occurrence of postoperative scar hyperplasia and the limited number, its clinical application is still limited. In contrast, allograft...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61L27/20A61L27/36A61L27/50A61L27/54
CPCA61L27/3608A61L27/365A61L27/20A61L27/50A61L27/54A61L2300/232A61L2300/412A61L2430/02C08L5/00
Inventor 徐钢赵彦涛李忠海张博程杨明曲巍张卫国
Owner FIRST AFFILIATED HOSPITAL OF DALIAN MEDICAL UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com