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Implant containing polysaccharide coating capable of binding growth factors and preparation method thereof

A growth factor, polysaccharide coating technology, applied in dental implants, medical science, dental prosthetics, etc., can solve the problems of low cost performance, long cycle, complicated preparation process, etc.

Active Publication Date: 2020-11-10
UNIVERSITY OF MACAU
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These methods have achieved certain experimental results, but there is still a big gap with clinical needs and the preparation process of these methods is complicated, the cycle is long, and the cost performance is low. For example, the existing technology cannot release growth factors in a controlled manner and there is a biosafety risk.

Method used

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  • Implant containing polysaccharide coating capable of binding growth factors and preparation method thereof
  • Implant containing polysaccharide coating capable of binding growth factors and preparation method thereof
  • Implant containing polysaccharide coating capable of binding growth factors and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation Embodiment 1

[0046] Anchor amino groups by plasma treatment: Use plasma-enhanced chemical vapor deposition equipment to anchor a layer of nano-thick amino groups on the surface of titanium sheets.

[0047] First, the vacuum chamber was pumped to 10Pa, argon gas was introduced, and the titanium sheet (substrate) was cleaned with Ar gas plasma for 10 minutes under the condition of power of 100W; The air pressure in the vacuum chamber reaches 21KPa; use acrylamine (ALA) with a purity of 99wt% as component steam to form an amine polymer deposition layer on the surface of the titanium metal substrate, turn on the power, adjust the discharge power to 150W, the frequency to 200kHz, and the initial steam pressure to 0.200mbar . Treat for 30 seconds to form a pinhole-free amino polymer film with a thickness of about 30nm on the surface, turn off the power to stop the discharge, continue to pass the monomer for 5 minutes, and then take out the sample for use.

preparation Embodiment 2

[0049] Dopamine copolymer film immobilizes amino groups: Utilizes the strong adhesion of dopamine to the surface of most materials to form a dopamine-polyethyleneimine (PEI) copolymer film rich in amino groups on the surface.

[0050] The ultrasonically cleaned titanium substrate was immersed in an alkaline dopamine solution (0.12 mg / ml 10 mM Tris solution, pH 8.5) for 30 minutes to allow dopamine to spontaneously oxidize and copolymerize. Then, a mixture of dopamine and PEI is added to the solution, so that the final concentration of PEI in the solution is 2 mg / ml, wherein a large amount of free amino groups lost by the copolymerization of dopamine are provided by PEI in the copolymerization film. Soak for one hour, rinse with deionized water, and vacuum dry for later use.

preparation Embodiment 3

[0052] Silane coupling agent anchoring method: use a general silane coupling agent (3-aminopropyl) triethoxysilane (APTES) to form a silane layer on the surface of the titanium sheet.

[0053] First, soak the titanium sheet substrate in a mixed solution of hydrogen peroxide and concentrated sulfuric acid (1:1) at room temperature for 40 minutes to activate hydroxyl groups on the surface for chemical connection with 2% APTES. The resulting titanium sheet was immersed in a 2% APTES toluene solution and allowed to stand for 1 hour. After the reaction, the titanium sheet was ultrasonically cleaned in acetone, blown dry with nitrogen, placed in an oven, heated at 110°C for 1 hour, and cooled for later use.

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Abstract

The invention relates to an implant containing a polysaccharide coating capable of binding to a platelet-derived growth factor, and a preparation method thereof. The implant containing the polysaccharide coating comprises an amino-anchored matrix, and the polysaccharide coating grafted onto the surface of the matrix and capable of binding to the growth factor.

Description

technical field [0001] The present invention relates to an implant containing a polysaccharide coating capable of binding growth factors and a preparation method thereof, specifically, the present invention relates to a titanium metal implant having an Eucommia polysaccharide coating capable of binding platelet-derived growth factors and its preparation method. Background technique [0002] At present, titanium metal implants often used in clinical implant surgery have high mechanical strength and good biocompatibility, but the patients are required to be healthy and the bone density of the implanted area is sufficient. However, many patients have insufficient bone density or decreased bone quality due to systemic diseases, resulting in bone defects that cannot accept bone implant surgery, or implants cannot form stable osseointegration, resulting in surgical failure. Therefore, it is necessary to develop bone implants that meet higher requirements, which have the biologica...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61C8/00
CPCA61C8/0013A61C8/0016
Inventor 王春明石雨琛李秋王一涛
Owner UNIVERSITY OF MACAU
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