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Stirring method of adsorption tank

A stirring method and adsorption tank technology, which is applied in the field of biomedicine, can solve problems such as prolonged operation time, clogged filter plates, and gel deformation, so as to ensure product yield and quality, prevent filter plate clogging, and protect gel form. Effect

Active Publication Date: 2020-11-17
SHANDONG TAIBANG BIOLOGICAL PROD CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Aiming at the problems that the gel is deformed and broken due to improper use of the stirrer, the filter plate is blocked, the operation time is greatly prolonged, and the smoothness of the process is seriously affected, and the stirring effect is not good, which affects the yield and quality of the product. The present invention provides A stirring method for an adsorption tank. The method of the invention can quickly calculate the stirring height, and limits parameters such as stirring time and rotating speed. Under the premise of ensuring the stirring effect, it can effectively avoid the deformation and breaking of the gel and the Prolonged or interrupted operation time due to this

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  • Stirring method of adsorption tank

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Embodiment 1

[0043] A stirring method for an adsorption tank, said method comprising (I) adjusting the stirring height according to the amount of gel and (II) selecting a stirrer 4, determining stirring parameters, and stirring;

[0044] The adjustment method of described stirring height comprises the steps:

[0045] (1) According to the amount of plasma absorbed by the gel 1000kg, use 1.5g of gel per kg of plasma, and determine the amount of gel M to be 1500g;

[0046] (2) Determine the minimum expansion ratio K of the gel in the solution m , including the following steps:

[0047] (21) The solution used for gel treatment includes swelling solution, equilibrium solution, washing solution, eluent, regeneration solution and preservation solution, and the swelling solution is 0.075mol / L sodium chloride solution,

[0048] Balance liquid is 0.08mol / L sodium chloride, 0.015mol / L sodium citrate, pH7.2±0.1,

[0049]The washing solution is 0.18mol / L sodium chloride, 0.015mol / L sodium citrate, p...

Embodiment 2

[0065] A stirring method for an adsorption tank, said method comprising (I) adjusting the stirring height according to the amount of gel and (II) selecting a stirrer 4, determining stirring parameters, and stirring;

[0066] The adjustment method of described stirring height comprises the steps:

[0067] (1) According to the amount of plasma absorbed by the gel 1500kg, use 1.2g of gel per kg of plasma, and determine the amount of gel M to be 1800g;

[0068] (2) Determine the minimum expansion ratio K of the gel in the solution m , including the following steps:

[0069] (21) The solution used for gel treatment includes swelling solution, equilibrium solution, washing solution, eluent, regeneration solution and preservation solution, and the swelling solution is 0.075mol / L sodium chloride solution,

[0070] Balance liquid is 0.08mol / L sodium chloride, 0.015mol / L sodium citrate, pH7.2±0.2,

[0071] The washing solution is 0.18mol / L sodium chloride, 0.015mol / L sodium citrate, ...

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Abstract

The invention relates to the technical field of biological medicines, in particular to a stirring method of an adsorption tank, which comprises the following steps: (I) adjusting the stirring height according to the gel consumption, (II) selecting a stirrer, determining stirring parameters, and stirring the material, wherein adjustment of the stirring height comprises the following steps: determining the gel dosage M, determining the minimum expansion ratio Km of the gel in the solution, calculating the minimum settling thickness h of the gel in the adsorption tank after settling, calculatingthe total height H of the liquid level in the adsorption tank, and adjusting the stirrer to enable the distance D between the lower edge of the stirrer and the filter plate to be between h-5 cm and H-2 cm. According to the method, the stirring height can be quickly calculated, parameters such as the stirring time and the rotating speed are limited; therefore, on the premise that the stirring effect is guaranteed, deformation and breakage of gel and operation time prolonging or interruption caused by deformation and breakage of the gel can be effectively avoided.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to a stirring method for an adsorption tank. Background technique [0002] Human Prothrombin Complex Concentrate (hereinafter referred to as PCC) is a concentrated preparation of four coagulation factors II, VII, IX, and X in human plasma. It is mainly used clinically for the treatment of congenital and acquired coagulation factors II, VII, IX, X deficiency. The existing equipment for separating and purifying PCC mainly includes adsorption tanks, expanded beds, and chromatographic columns, and the separation medium mainly uses DEAE Sephadex A-50 gel. [0003] Gel is a kind of weak anion exchange gel, the diameter of dry gel particles is 40-125μm, its state in solution is affected by solution pH and ionic strength, and has different expansion ratios, for example, in 0.15mol / L chlorination In sodium solution, the diameter of gel particles is 214 μm, and in 0.50 mol / L sodium chlo...

Claims

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Application Information

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IPC IPC(8): B01D15/04B01D15/02
CPCB01D15/02
Inventor 乔福锋师秀梅李斌冯卫国郑志华许庆祥吴奇骏陈政
Owner SHANDONG TAIBANG BIOLOGICAL PROD CO LTD
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