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Narrow-beam X-ray excited luminescence tomography method based on U-net network

A luminescent tomography and X-ray technology, which is applied in the fields of biomedical engineering and medical imaging, can solve the problems of short scanning time, low spatial resolution of reconstructed images, and long imaging time to limit the research of living animals.

Inactive Publication Date: 2020-11-17
TIANJIN UNIV
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Problems solved by technology

The obvious advantages of the cone-beam XLCT system are short scan time and high utilization of X-rays, but the spatial resolution of the reconstructed image is low due to its lack of "excitation prior"; the narrow-beam XLCT system has the advantage of higher spatial resolution , but its long imaging time limits the study of live animal experiments

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  • Narrow-beam X-ray excited luminescence tomography method based on U-net network
  • Narrow-beam X-ray excited luminescence tomography method based on U-net network
  • Narrow-beam X-ray excited luminescence tomography method based on U-net network

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Embodiment Construction

[0016] In order to make the technical solution of the present invention clearer, the present invention will be further elaborated below in conjunction with the accompanying drawings. The present invention is concretely realized according to the following steps:

[0017] The first step is to generate a simulated dataset:

[0018] (1) Forward model construction: According to the optical theory, the propagation process of photons in biological soft tissues can be described by the radiative transfer equation

[0019] ("Biomedical Photonics", Xu Kexin, Gao Feng, Zhao Huijuan), due to the high scattering and low absorption properties of biological soft tissue to near-infrared light, this equation is generally approximated as a diffusion equation, so the imaging model can be expressed as:

[0020] (where μ a (r) is the absorption coefficient, Φ(r) is the luminous flux density, D(r)=(3(μ a (r)+(1-g)μ s (r))) -1 is the diffusion coefficient, g is the anisotropy parameter, μ s (...

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Abstract

The invention relates to a narrow-beam X-ray excited luminescence tomography method based on a U-net network. The method comprises the following steps: generating an analog data set; training the U-net network: modifying the U-net network, reserving an upper sampling part, a lower sampling part and a jump connection layer of the original network, connecting a full connection layer on the basis ofthe U-net network to output the density of fluorescent nanoparticles at each node of the dissected phantom, and calculating the loss value of the fluorescent nanoparticles by using a sum of squares and a loss function; training a network model by using the obtained analog data set, and learning effective information in the measurement signal; and adjusting the network and testing the network model.

Description

technical field [0001] The invention belongs to the fields of biomedical engineering and medical imaging, and relates to a novel method for excitation luminescence tomography of narrow-beam X-rays based on a U-net network. Background technique [0002] X-Ray Luminescence Computed Tomography (XLCT) technology is a new type of optical molecular imaging technology, which has the characteristics of high spatial resolution and deep detection depth, and can simultaneously realize structural imaging and optical molecular imaging. Therefore, it has received extensive attention from scholars at home and abroad. Traditional CT imaging belongs to anatomical imaging, which provides structural information of biological tissues, but cannot detect physiological and pathological functional changes in biological tissues, especially specific changes, which can only be displayed on CT images when tissue morphology changes in the lesion area , so it cannot be diagnosed in the early stage of di...

Claims

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Application Information

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IPC IPC(8): G06T17/20G06N3/04G06N3/08A61B6/03
CPCG06T17/20G06N3/08A61B6/032A61B6/52G06N3/045
Inventor 周仲兴李银娇孙东榆高峰
Owner TIANJIN UNIV
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