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A kind of Dioscorea japonica extract with whitening, anti-inflammatory, safe and non-allergenic properties and preparation method thereof

An extract, the technology of yam yam, applied in the field of preparation of yam extract, can solve the problems of skin irritation, limited wide use, poor whitening and anti-inflammatory effects, etc., and achieve the effect of skin safety

Active Publication Date: 2022-07-01
SHANGHAI HUIWEN BIO TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The existing extraction process of active ingredients in yam can not simultaneously remove the itching ingredients and effectively retain the main active ingredients polysaccharides and saponins in yam: the active ingredients in yam extract are too low, and the whitening and anti-inflammatory effects are not good , and the itch-causing components in the yam extract cannot be effectively removed, and the yam extract will cause irritation to the skin, no matter what the situation is, it has limited its wide use in the field of cosmetics

Method used

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  • A kind of Dioscorea japonica extract with whitening, anti-inflammatory, safe and non-allergenic properties and preparation method thereof
  • A kind of Dioscorea japonica extract with whitening, anti-inflammatory, safe and non-allergenic properties and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Example 1: Preparation of Dioscorea officinalis extract

[0042] A preparation method of Dioscorea chinensis extract, the method comprises the following steps:

[0043] (1) Cleaning:

[0044] Wash with tap water to remove impurities such as sediment on the surface of yam root;

[0045] (2) Crush:

[0046] Dioscorea root is pulverized into small particles with a pulverizer;

[0047] (3) Extract:

[0048] Put the pre-crushed Dioscorea Root into the extraction tank, add 4 times to 8 times the weight of the raw material in pure water, heat up to 70°C to 90°C, add 0.05% to 5% (w / w) of high-temperature amylase, and extract by heat preservation. 1 to 6 hours. After the extraction, filter while hot to obtain the crude filtrate of Dioscorea oleracea extract, and discard the filter residue;

[0049] (4) Enzymatic hydrolysis:

[0050] The crude filtrate, adjust the temperature to 40℃~60℃, add 0.05%~5% (w / w) protease, keep the enzymolysis for 1~6 hours, the enzymolysis is fi...

Embodiment 2

[0082] Example 2: Patch Test

[0083] The patch test was conducted in accordance with the "Cosmetics Safety Technical Specifications". A total of 30 subjects were selected for the patch test, ranging in age from 21 to 52 years old, including 18 females and 12 males. Pipette 0.025mL of Dioscorea officinalis extract and blank control distilled water, and drop them on the filter paper respectively. The patch tester with the test substance was applied to the subject's forearm curve, and lightly pressed with the palm of the hand to make it evenly applied to the skin for 24 hours. The results showed that all subjects had no adverse reactions, indicating that Dioscorea japonica extract was not irritating to the skin. As shown in Table 1 in Example 1, the extracts of Dioscorea officinalis obtained according to Method 2, Method 3, Method 4 and Method 5 in Example 1 also had similar effects.

Embodiment 3

[0084] Example 3: Eye irritation test

[0085] Chick chorioallantoic membrane (CAM) test for cosmetic eye irritation / corrosion according to standard SNT 2329-2009. Take 0.3 ml of Dioscorea chinensis extract (prepared according to method 1 in implementation 1) and drop it directly on the surface of CAM, observe the reaction of CAM, and record the time when each toxic effect appears within 5 minutes. Bleeding, coagulation, and vascular melting were scored separately. The results showed that the irritant scores of Dioscorea officinalis extract were all 0.07 points, which proved that Dioscorea extract had no eye irritation. Similarly, the Dioscorea japonica extracts obtained according to Method 2, Method 3, Method 4 and Method 5 in Example 1 also achieved similar effects.

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Abstract

The invention discloses a preparation method of a diosgenus extract with whitening, anti-inflammatory, safe and non-allergenic properties. The preparation method mainly includes enzymatic hydrolysis, resin adsorption and decolorization. Itching ingredients, while retaining the active ingredients of Dioscorea polysaccharides and saponins. The prepared Dioscorea chinensis extract is safe and non-irritating to the skin, has whitening and anti-inflammatory effects, and can be used in cosmetics.

Description

technical field [0001] The invention belongs to a preparation method of a Dioscorea officinalis extract with whitening, anti-inflammatory, safe and non-allergenic properties, and more particularly, relates to a Dioscorea officinalis extract suitable for use in cosmetics and a preparation method thereof. Background technique [0002] Dioscorea, also known as yam, was first recorded in "Shen Nong's Herbal Classic" and is a traditional Chinese health food. Modern research shows that the main active ingredients in Dioscorea are polysaccharides and saponins, which have the functions of lowering blood sugar, lowering blood lipids, anti-oxidation, anti-aging, enhancing immunity and anti-tumor. [0003] It has been reported that yam polysaccharide has good hygroscopicity, moisture retention and transdermal absorption. The existing technology for preparing yam polysaccharide uses 95% ethanol, acetone, ether and the like. This process only obtains the target component polysaccharide...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/9794A61Q19/02A61P29/00
CPCA61K8/9794A61Q19/02A61P29/00A61K2800/805A61K2800/782
Inventor 骆峰金荣熙李惠董婷婷李国光费维成
Owner SHANGHAI HUIWEN BIO TECH
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