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Inflatable bioreactor and method of use

A technology of bioreactor and film, applied in the direction of biochemical equipment and methods, bioreactor/fermenter combination, specific-purpose bioreactor/fermenter, etc., can solve unsolved problems such as improving oxygenation

Pending Publication Date: 2020-11-24
GLOBAL LIFE SCI SOLUTIONS USA LLC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] International Publication No. WO 2012 / 128703 addresses the need for better oxygenation by means of a vertically extending shield in the bag, but the design described does not address the need for improved oxygenation at low initial volumes

Method used

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  • Inflatable bioreactor and method of use
  • Inflatable bioreactor and method of use
  • Inflatable bioreactor and method of use

Examples

Experimental program
Comparison scheme
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Embodiment Construction

[0036] figure 1 Shown is a perfusion cell culture bioreactor system 100 (which may also be referred to herein as a "bioreactor system," a "rockable bioreactor system," or a "bioreactor system" in accordance with one or more embodiments of the present disclosure. Components") and their components and features. As described below, bioreactor system 100 may be used to grow cells or other biological materials. For example, bioreactor system 100 may receive and agitate cell culture medium 10 (which may also be referred to herein as "culture broth" or "culture fluid") to provide the aeration and mixing necessary for cell culture. As shown, bioreactor system 100 may include bioreactor 110 , tray 140 , pivot block 150 and actuator 160 . It will be understood that, figure 1 A bioreactor system 100 is schematically shown in , and according to various embodiments, the bioreactor system 100 may include additional components and / or features.

[0037] Such as figure 1 During operation ...

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PUM

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Abstract

An inflatable bioreactor (110, 210) may include one or more sheets joined to form a bag (111, 211) including a top sheet (118, 218) and a bottom sheet (119, 219) formed from the one or more sheets andbeing inflatable to provide an internal volume (117, 217) suitable for retaining a volume of culture liquid (10) during flow of the culture liquid resulting from a rocking motion (R) of the bag, andone or more perturbing protrusions (116, 116', 116'', 216) extending upwardly from the bottom sheet toward, but not as far as, the top sheet and extending transversely to, or obliquely to, a directionof wave motion (W) of the culture liquid. The resulting construction may provide improved flow for low initial volumes of the culture liquid in the bag.

Description

[0001] Cross References to Related Applications [0002] This application claims the benefit of U.S. Provisional Application No. 62 / 662,292, filed April 25, 2018, the entire contents of which are incorporated herein by reference. technical field [0003] The present disclosure generally relates to improvements in flexible bioreactors formed from flexible sheets, such as substantially self-supporting types configured as bags or bag-like containers for fluids for culturing cells or other biological materials , and more particularly to an inflatable flexible bag bioreactor for such cultivation under agitation (eg rocking). The present disclosure also relates to improved bioreactor assemblies. Background technique [0004] Traditionally, the bioprocessing industry has used stainless steel systems and piping in manufacturing processes for fermentation and cell culture. These devices are designed to be steam sterilizable and reusable. However, cleaning and sterilization are exp...

Claims

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Application Information

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IPC IPC(8): C12M1/00C12M3/06
CPCC12M23/14C12M27/16C12M27/20C12M41/22C12M29/10C12M25/10
Inventor H·绍科宁R·斯坦科夫斯基
Owner GLOBAL LIFE SCI SOLUTIONS USA LLC