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Application of hydroxy-alpha-sanshool in preparation of medicine for regulating blood glucose

A technology of sanshool and hydroxyl, applied in the field of medicine, can solve the problems of lack of research on the therapeutic effect of diabetes

Inactive Publication Date: 2020-11-27
WEST CHINA HOSPITAL SICHUAN UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Studies have confirmed that HαSS can improve lipid metabolism and reduce inflammation, but there is a lack of research on its therapeutic effect on diabetes

Method used

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  • Application of hydroxy-alpha-sanshool in preparation of medicine for regulating blood glucose
  • Application of hydroxy-alpha-sanshool in preparation of medicine for regulating blood glucose
  • Application of hydroxy-alpha-sanshool in preparation of medicine for regulating blood glucose

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Embodiment Construction

[0022] In order to make the object, technical solution and advantages of the present invention more clear, the present invention will be further described in detail below in conjunction with the examples. It should be understood that the specific embodiments described here are only used to explain the present invention, not to limit the present invention.

[0023] Extraction and identification of formula 1 compound hydroxyl-alpha-sanshool involved in the present invention: by means of medium pressure column chromatography system (MPLC) and preparative liquid chromatography (Pre-HPLC), it is separated from Zanthoxylum bungeanum low polarity component High-purity active ingredient; compared with the reference substance, it is confirmed that the active ingredient is hydroxy-α-sanshool by comparing the ultraviolet spectrum, liquid phase retention time and mass spectrometry analysis.

[0024] The present invention reveals the effect of hydroxyl-α-sanshool on protecting the function...

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Abstract

The invention discloses application of hydroxy-alpha-sanshool in preparation of a medicine for regulating blood glucose. Hydroxy-alpha-sanshool and pharmaceutically acceptable accessories or carriersare prepared into an oral preparation, which can be used as a medicine for regulating blood glucose; the medicine has the effects of improving the islet beta-cell function of a person or animal and reducing the blood glucose of the person or animal; the mass percentage content of the hydroxy-alpha-sanshool in the medicine for regulating blood glucose can be 0.1% to 100%; the technical personnel inthe field can easily determine the administration dosage according to an actual situation; due to oral administration of the hydroxy-alpha-sanshool in the invention, the blood glucose of a metabolicsyndrome model mouse can be decreased significantly; simultaneously, the HOMA-beta index is obviously increased; and it shows that the hydroxy-alpha-sanshool can be used for treating diabetes.

Description

technical field [0001] The invention relates to the field of medicine, discloses that hydroxy-α-sanshool lowers blood sugar by improving the function of pancreatic beta cells, provides a drug for treating diabetes with definite curative effect and controllable quality, and can meet the needs of clinical application. It has been verified by experiments that hydroxy-α-sanshool can significantly reduce blood sugar in mice with metabolic syndrome induced by high-fat and high-cholesterol diet, and protect the function of pancreatic β-cells. Background technique [0002] Epidemiological studies have shown that with the continuous improvement of people's living standards and changes in eating habits, the global incidence and mortality of diabetes continue to increase, and the age of onset is gradually becoming younger. [0003] The etiology and pathogenesis of type 2 diabetes are still unclear, and its remarkable pathophysiological feature is the decline in the ability of insulin t...

Claims

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Application Information

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IPC IPC(8): A61K31/164A61P3/10A61P5/50
CPCA61K31/164A61P3/10A61P5/50
Inventor 周方励
Owner WEST CHINA HOSPITAL SICHUAN UNIV
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