A kind of effervescent gel dry powder preparation and preparation method thereof

A dry powder preparation and gel technology, which is applied in the directions of food ingredients as gelling agents, food ingredients as foaming agents, bacteria used in food preparation, etc.

Active Publication Date: 2022-07-15
NINGBO FOCUS BIOMEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Due to the defects of gels in the current market, it is far from meeting the needs of infants and some patients with special swallowing reflex dysfunction, and the current gels are not freshly prepared, have poor taste, and are not easy to be widely used

Method used

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  • A kind of effervescent gel dry powder preparation and preparation method thereof
  • A kind of effervescent gel dry powder preparation and preparation method thereof
  • A kind of effervescent gel dry powder preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] The above are only specific implementation cases of the present invention, and the protection scope of the present invention is not limited thereto. Any modification or replacement of the present invention by any person skilled in the art within the technical specifications of the present invention shall be within the protection scope of the present invention.

[0024] In the present embodiment, firstly prepare the fast-swelling gelling agent particles, and the production process of the fast-swelling gelling agent particles is as follows:

[0025] 500 grams of Carbomer 971P was placed in a pot of a wet granulator, and the Carbomer 971P was heated with a 95-degree water bath through the interlayer of the pot. Under the stirring of the stirring paddle at 15 rpm, the temperature of Carbomer 971P will gradually increase. When the temperature reaches 85-90 degrees, 320 grams of polyethylene glycol 6000 (PEG6000) particles are slowly poured into the pot of the wet granulator....

Embodiment 2

[0030] In this example, firstly, the fast-swelling gelling agent particles are prepared, and the preparation process of the fast-swelling gelling agent particles is completely consistent with the preparation process of the fast-swelling gelling agent particles described in Example 1.

[0031] Take 10 g of the quick-swelling gel particles prepared above, 10 g of active pharmaceutical ingredients, 3 g of foaming agent, 73 g of flavoring agent, 3 g of flavor-masking agent, and 1 g of coloring agent. Mix well to prepare 100 g of the effervescent gel dry powder formulation of this example. The specific compounds used in the pharmaceutical active ingredients, foaming agents, flavoring agents, taste-masking agents and coloring agents used in this example are shown in Table 2 below.

[0032] Table 2

[0033]

[0034]

Embodiment 3

[0036] In this example, the fast-swelling gelling agent particles are first prepared, and the preparation process of the fast-swelling gelling agent particles is completely consistent with the preparation process of the fast-swelling gelling agent particles described in Example 1.

[0037] Take 12 g of the quick-swelling gel particles prepared above, 8 g of active pharmaceutical ingredients, 4 g of foaming agent, 72 g of flavoring agent, 3 g of flavor-masking agent, and 1 g of coloring agent. Mix well to prepare 100 g of the effervescent gel dry powder formulation of this example. The specific compounds used in the pharmaceutical active ingredients, foaming agents, flavoring agents, taste-masking agents and coloring agents used in this example are shown in Table 3 below.

[0038] table 3

[0039] Element specific compound Pharmaceutical active ingredients Cefaclor Foaming agent sodium bicarbonate flavoring agent Xylitol taste masking agen...

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Abstract

The invention relates to a novel oral preparation platform: effervescent gel (Effervescent gel EG) agent. It is mainly composed of a quick-swelling gelling agent, a foaming agent, an active ingredient and an auxiliary ingredient. The effervescent gel is mixed with an appropriate amount of water or aqueous solution, which can quickly (generally less than 30 seconds) expand and form a uniform multi-foam hydrogel. The dosage form has the advantages of fast gel formation, convenient preparation, uniform gel and smooth taste. The characteristics of smoothness and adjustable viscosity are especially suitable for children, the elderly and patients with swallowing reflex dysfunction. Oral effervescent gel is convenient, safe and has excellent taste, which significantly increases the compliance of children and patients, and can be used in the fields of medicine, food and health care products.

Description

technical field [0001] The invention relates to an oral preparation for medicine, food and health care products, in particular to an effervescent gel dry powder preparation and a preparation method thereof. Background technique [0002] Oral preparations generally include tablets, capsules, suspensions, granules, solutions, syrups, gels, and the like. For infants and young children and some patients with special swallowing reflex dysfunction, due to their age, body or disease, the swallowing reflex is impaired, and during the swallowing process, aspiration is easy to occur, oral liquid or solid. Inhaled into the trachea, resulting in aspiration pneumonia or suffocation or even death. Therefore, the most suitable oral dosage form for them is a gel with a certain viscosity and the viscosity can be adjusted. A certain viscosity can make the gel adhere to the mucous membranes of the oral cavity and pharynx, and can only enter the esophagus by swallowing, and prevent aspiration...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/06A23L2/40A23L33/135A23L33/14A61K47/32A61K47/10A61K47/02A61K31/545A61P31/04
CPCA23L2/40A23L33/135A23L33/14A61K9/06A61K9/0053A61K9/0007A61K47/32A61K47/10A61K47/02A61K31/545A61P31/04A23V2002/00A23V2400/113A23V2400/175A23V2400/51A23V2200/04A23V2200/16A23V2200/226A23V2200/228A23V2200/30A23V2250/1614A23V2250/76A61K31/167A61K31/485A61K31/192A61K9/0095
Inventor 张秋野王岩松
Owner NINGBO FOCUS BIOMEDICAL TECH CO LTD
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