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Oral Nicotinamide adenine dinucleotide (NAD+) precursor oral supplementation formulation to support physiological functions associated with aging in humans

A technology of nicotinamide adenine and supplements, which can be applied to medical preparations containing active ingredients, anti-toxins, drug combinations, etc., and can solve problems such as reducing the risk of cardiovascular diseases

Inactive Publication Date: 2020-12-04
国际批发集团有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

On the other hand, niacin, also known as nicotine, or nicotinic acid, is an organic compound and a form of vitamin B3, an essential nutrient used in the treatment of hypercholesterolemia but not yet Concomitant use with statins (reference) was observed to reduce the risk of cardiovascular disease, unlike nicotinamide, which has no hypolipidemic effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0025] The present invention provides a novel and innovative oral nicotinamide adenine dinucleotide (NAD+) precursor oral supplement formulation that supports physiological functions associated with human aging.

[0026] The technical solution of the present invention is: an oral supplement (400mg), which has NAD+ precursor (nicotinamide 10mg; niacin 50mg) (herein collectively referred to as NAD+), and also contains ascorbic acid (100mg), chromium picolinate (50μg) , magnesium oxide (50 mg), quercetin (100 mg), said oral supplements can prevent and / or treat obesity by improving glucose tolerance associated with high-fat dietary intake.

[0027]Further, both nicotine (nicotinic acid) and nicotinamide are precursors of NAD+ and NADP (nicotinamide adenine dinucleotide phosphate), and the combination of NAD+ supplement (400 mg) with ascorbic acid, quercetin can be obtained by Minimizes oxidative stress by alleviating the production of free radicals (anti-aging effect).

[0028] F...

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PUM

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Abstract

The invention discloses a oral Nicotinamide adenine dinucleotide (NAD+) precursor oral supplementation formulation to support physiological functions associated with aging in humans. The oral supplement (400 mg) having an NAD+ precursor (10 mg nicotinamide; the present invention relates to an oral supplement (50 mg of nicotinic acid) (collectively referred to herein as NAD+), further comprising ascorbic acid (100 mg), chromium picolinate (50 [mu]g), magnesium oxide (50 mg), and quercetin (100 mg), which can prevent and / or treat obesity by improving glucose tolerance associated with high fat diet intake.

Description

technical field [0001] The present invention relates to a novel and innovative oral nicotinamide adenine dinucleotide (NAD+) precursor oral supplement formulation that supports physiological functions associated with human aging. Background technique [0002] NAD + Oral supplements have been used in a variety of treatments. Current technologies include: prevention and treatment of obesity or impaired glucose tolerance in high-fat diet intake, suppression of weight gain due to high calorie intake, and improvement of glucose tolerance via injection of NAD+ (2 pmol). [0003] Nicotinamide adenine dinucleotide (NAD+) precursor oral supplement formulation (400 mg) combines 100 mg of ascorbic acid (also known as ascorbic acid or vitamin C), a water-soluble antioxidant. The role of ascorbic acid is to scavenge free radicals and reactive oxygen species (ROS) (i.e., O 2 - 、H 2 o 2 , OH - 、ONOO - ). Exercise may cause an imbalance between ROS and antioxidants, leading to oxid...

Claims

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Application Information

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IPC IPC(8): A61K33/08A61P3/04A61P39/06A61P25/00A61P9/10A61P3/06A61P3/10A61P5/50A61P21/00A61P9/12A61K31/455A61K31/375A61K31/555A61K31/352
CPCA61K31/455A61K31/375A61K33/08A61K31/353A61K33/24A61P3/10A61P9/10A61P25/28A61P3/04A61K2300/00A61K31/555A61K31/352A61P39/06A61P25/00A61P3/06A61P5/50A61P21/00A61P9/12
Inventor 西蒙·安吉洛·奇凯洛
Owner 国际批发集团有限公司