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Coronary drug-coated balloon

A drug coating and balloon technology, applied in coatings, balloon catheters, catheters, etc., can solve the problems of increasing patient pain, increasing contact area, secondary injury to patients, etc. The effect of avoiding secondary damage

Inactive Publication Date: 2020-12-25
浙江桐轩医疗科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At the same time, the lesion is pre-expanded by the ordinary balloon, which increases the area where the inner wall of the blood vessel in the lesion can contact the surface of the drug-coated balloon, increases the amount of drug transferred to the blood vessel wall after the expansion of the drug-coated balloon, and improves the Therapeutic effect, however, pre-dilation requires the use of additional ordinary balloons, which not only increases the complexity of the operation, prolongs the operation time, but also increases the economic burden of the patient. At the same time, even after the pre-dilation, drug coating is still unavoidable The loss caused by the high-speed flow of blood washing the balloon during the delivery process, and when it is in use, the balloon is easily affected by the internal pressure of the human body during the expansion process, and the contraction and reset actions often occur, causing secondary damage to the patient. injury, increased patient suffering

Method used

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Examples

Experimental program
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Effect test

preparation example Construction

[0041] In this application, the preparation method of TPU refers to the following steps:

[0042] (1) Add polylactic acid to N,N-dimethylformamide, after the polylactic acid dissolves completely and becomes transparent, then add isophorone diisocyanate, heat up to 50-70°C under nitrogen atmosphere, and react 30-90 minutes;

[0043](2) in step (1), add 1,4-butanediol, fully mix, detect reaction end point with infrared spectrum, treat to be unable to detect NCO (the absorption peak of NCO group is 2226cm -1 ), the reaction ends.

[0044] In some preferred embodiments, the polylactic acid has a weight average molecular weight of 60,000.

[0045] Polylactic acid, product number LM1221, was purchased from Shanghai Lianmai Bioengineering Co., Ltd.

[0046] In some preferred embodiments, the weight ratio of POM to TPU is 1:0.5-2.

[0047] In this application, the combination of POM and TPU can be used to solve the problems of low notched impact strength and poor toughness of POM ...

Embodiment 1

[0080] see Figure 1-3 , the present invention provides a coronary drug-coated balloon, comprising a balloon body 1, an introduction head 2 is arranged on the left side of the balloon body 1, and a reference column 3 is arranged in the inner cavity of the introduction head 2, and the reference column 3 The middle part is provided with a compensation chamber 4, the middle part of the outside of the balloon body 1 is provided with a coating 5, the inner cavity of the reference column 3 is connected with a fine-tuning shaft 6, and the outer ring of the compensation chamber 4 is equidistantly connected with a support piece 401, and the support piece 401 is fixedly welded with a support arc 402 at one end located outside the compensation chamber 4, and is fixedly welded with a trimming tile 403 at one end of the support plate 401 located in the inner cavity of the compensation chamber 4, and the fine-tuning shaft 6 is fixedly welded at an equal distance up the outer ring of the inne...

Embodiment 2

[0082] A coronary drug-coated balloon, the preparation raw materials are calculated in parts by weight, including: 50 parts of POM, 50 parts of TPU, 0.1 part of modified nano-zinc oxide, 0.2 part of chitosan, 0.1 part of peppermint extract, and geranium extract 0.1 part.

[0083] The average particle size of the modified nano zinc oxide is 60nm.

[0084] POM, brand N2720 M63, was purchased from BASF, Germany; chitosan, brand C804726, deacetylation degree ≥ 95%, was purchased from Shanghai Macklin Biochemical Technology Co., Ltd.

[0085]The raw materials for TPU preparation include, in parts by weight, 20 parts of polylactic acid, 45 parts of isophorone diisocyanate, 12 parts of 1,4-butanediol, and 150 parts of N,N-dimethylformamide.

[0086] The weight-average molecular weight of polylactic acid is 60000, and the article number is LM1221, purchased from Shanghai Lianmai Bioengineering Co., Ltd.

[0087] The preparation method of TPU refers to the following steps:

[0088] ...

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PUM

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Abstract

The invention discloses a coronary drug-coated balloon. The balloon includes a balloon body; the left side of the balloon body is provided with a leading-in head; a reference column is arranged in theinner cavity of the leading-in head; the middle part of the reference column is provided with a compensation cabin; the middle part on the outer side of the balloon body is provided with a coating; fine-tuning shaft is in penetrated connection with the inner cavity of the reference column; supporting pieces equidistantly penetrate the outer ring of the compensation cabin; the ends, located on theouter side of the compensation cabin, of the supporting pieces are fixedly welded with supporting arcs; the ends, located in the inner caivty of the compensation cabin, of the supporting pieces are fixedly welded with fine-tuning tiles; and the outer ring upper line, located in the inner cavity of the compensation cabin, of the fine-tuning shaft is equidistantly and fixedly welded with tighteningblocks. Through the design of one-way cyclic operation, the contact area of the balloon and the coating with the internal of a human body can be controlled, the expanded size of the balloon cannot beeasily changed even affected by the pharmacology of the inner wall, so that the contact area of the coating cannot be influenced, namely, the problems of the change of coating area of the drug coating cannot occur.

Description

technical field [0001] The invention belongs to the technical field of medical devices, and more specifically relates to a coronary drug-coated balloon. Background technique [0002] Arterial stenosis has always been a kind of disease that plagues human beings. In order to cure this kind of disease, medical treatment methods such as bare balloon, bare stent, and drug-eluting stent have been used successively. However, the aforementioned treatment options have different defects. So the drug-coated balloon catheter came into being. It not only creates a channel for blood circulation through balloon expansion, but also the drug loaded on the balloon can effectively inhibit the proliferation of smooth muscle cells and prevent vascular restenosis. When using drug-coated balloon Before dilating the lesion, it is necessary to pre-expand the lesion with an ordinary drug-free balloon, so that the drug-coated balloon can enter the lesion smoothly. At the same time, the lesion is pre-...

Claims

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Application Information

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IPC IPC(8): A61M25/10A61L29/00A61L29/02A61L29/04A61L29/06A61L29/14A61L29/16
CPCA61L29/005A61L29/02A61L29/043A61L29/06A61L29/14A61L29/16A61L2300/102A61L2300/416A61L2300/606A61M25/10A61M2025/105A61M2025/1075C08L75/06C08L5/08C08L59/02
Inventor 沈坤
Owner 浙江桐轩医疗科技有限公司
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