Alkaloid compound and its preparation method and use

Abstract

The invention belongs to the technical field of medicine, and relates to alkaloid compounds and their preparation methods and medical applications, in particular to morphinanes and bisbenzylisoquinoline alkaloids and their preparation methods and their preparation for the prevention or treatment of neurodegenerative diseases, Application in antitumor drugs, the structure of the compound is as follows: wherein, R 1 , R 2 is hydroxyl, C1‑C4 acyl; R 3 is C1‑C4 aldehyde group, R 4 , R 9 is C1‑C4 alkoxy, R 5 for hydrogen, R 6 and R 7 form methylenedioxy, R 8 is C1‑C4 alkyl; R 1 'is C1‑C4 alkyl, R 2 ', R 3 ', R 5 ', R 7 'is C1‑C4 alkoxy, R 4 ' is hydrogen, R 6 ' is a C1-C4 aldehyde group.

Description

technical field

[0001] The invention belongs to the technical field of medicine and relates to alkaloid compounds and their preparation methods and applications, in particular to four morphinane alkaloids and two bisbenzylisoquinoline alkaloids and their preparation methods and applications. Background technique

[0002] Baiyaozi (Stephania cepharantha Hayata) is the dry root tuber of Stephania cepharantha plant of the family Fangjiceae, also known as mountain turtle and Baiyao. It is mainly distributed in the south of the Yangtze River and other places. It is a commonly used herbal medicine in the folk. It has the effects of clearing away heat and detoxification, reducing swelling and pain, antibacterial and anti-inflammatory.

[0003] As a traditional Chinese medicine, the name "Baiyao" was first recorded in "Xinxiu Materia Medica", saying that it "taste is pungent, warm, non-toxic; it is mainly used for golden sores and muscle growth". Then there are records in "Tu Jing ...

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