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Pharmaceutical composition for treating psoriasis and preparation method thereof

A composition and psoriasis technology, applied in the field of medicine, can solve the problems of large toxic and side effects, poor tolerance of patients, etc., and achieve the effect of small side effects, slow onset of treatment, and definite curative effect

Inactive Publication Date: 2021-01-05
ZHUOHE PHARM GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Compared with traditional Chinese medicine, western medicine treatment generally has the characteristics of quick onset, can obtain certain curative effect in a short period of time, and has certain clinical advantages. However, most of the current western medicines have relatively large toxic and side effects, poor patient tolerance and other factors.

Method used

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  • Pharmaceutical composition for treating psoriasis and preparation method thereof
  • Pharmaceutical composition for treating psoriasis and preparation method thereof
  • Pharmaceutical composition for treating psoriasis and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Compound (I) in this example, A is -COONa; B is C; R 1 for CH3; R 2 is OH; R 3 for H.

[0036] The pharmaceutical composition disclosed in this embodiment for the treatment of psoriasis comprises the following components and dosage:

[0037] Element Dosage / tablet Compound (Ⅰ) 10g ethanol 50g carbomer 10g Polysorbate 80 1.5g glycerin 30g Parabens 0.8g sodium hydroxide 2.5g Laurocaprazine 1.5g water Add to 1000g

[0038] This embodiment also discloses the preparation method of the above-mentioned pharmaceutical composition for treating psoriasis, comprising the following steps:

[0039] Step 1: Dissolving compound (I) in ethanol, then adding paraben and laurocaprazine and stirring evenly;

[0040] Step 2: Stir and dissolve the carbomer in 500g of water, dissolve the sodium hydroxide in 50g of water, then add the aqueous sodium hydroxide solution into the carbomer solution, and stir until it becomes ...

Embodiment 2

[0044] In the compound (I) of the present embodiment, A is -CF3; B is C; R 1 is OH; R 2 is OH; R 3 It is a C6 membered heterocycloalkyl group.

[0045] The pharmaceutical composition disclosed in this embodiment for the treatment of psoriasis comprises the following components and dosage:

[0046] Element Dosage / tablet Compound (Ⅰ) 10g ethanol 50g carbomer 10g Polysorbate 80 1.5g glycerin 30g Parabens 0.8g Triethanolamine 6g Laurocaprazine 1.5g water Add to 1000g

[0047] This embodiment also discloses the preparation method of the above-mentioned pharmaceutical composition for treating psoriasis, comprising the following steps:

[0048] Step 1: Dissolving compound (I) in ethanol, then adding paraben and laurocaprazine and stirring evenly;

[0049] Step 2: Stir and dissolve the carbomer in 500g of water, dissolve the triethanolamine in 50g of water, then add the triethanolamine aqueous solution into the ...

Embodiment 3

[0053] In the compound (I) of the present embodiment, A is -CF3; B is C; R 1 is OH; R 2 is OH; R 3 It is a C3 membered heterocycloalkyl group.

[0054] The pharmaceutical composition disclosed in this embodiment for the treatment of psoriasis comprises the following components and dosage:

[0055] Element Dosage / tablet Compound (Ⅰ) 10g Glyceryl monostearate 50g stearic acid 1.5g glycerin 80g paraffin 30g vaseline 50g Parabens 0.8g Poloxamer 5g Triethanolamine 6g Laurocaprazine 1.5g water Add to 1000g

[0056] This embodiment also discloses the preparation method of the above-mentioned pharmaceutical composition for treating psoriasis, comprising the following steps:

[0057] Step 1: The compound (I) is jet-pulverized to a particle size of ≤5 μm, and then added to glycerin to disperse evenly, then add paraben and laurocaprazine and stir evenly, then add vaseline and paraffin to disperse evenly; ...

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Abstract

The invention discloses a pharmaceutical composition for treating psoriasis. The pharmaceutical composition consists of a compound and auxiliary materials, wherein the compound has a structure shown in the specification and has the effect of treating psoriasis.

Description

technical field [0001] The invention relates to the technical field of medicine, and more specifically relates to a pharmaceutical composition for treating psoriasis and a preparation method thereof. Background technique [0002] Psoriasis is commonly called as psoriasis, is a kind of chronic inflammatory skin disease, is also called " white boil ", or " pine skin tinea " in my country, and the course of disease is long, has easy recurrence tendency, and some cases almost never heal all one's life. The incidence of this disease is mainly in young adults, and the worldwide incidence rate is about 2%, and the incidence rate in our country is about 0.47%, which has a great impact on the physical health and mental status of patients. The clinical manifestations are mainly erythema and scales, and the disease can occur all over the body. The scalp and the extensor sides of the limbs are more common, and it usually aggravates in winter. [0003] Modern medicine has done a lot of ...

Claims

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Application Information

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IPC IPC(8): A61K31/519A61K31/53A61K9/06A61K47/36A61K47/12A61K47/10A61P17/06
CPCA61K9/06A61K31/519A61K31/53A61K47/10A61K47/12A61K47/36A61P17/06
Inventor 张峰李晓明
Owner ZHUOHE PHARM GRP CO LTD
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