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Diagnostic biomarker tenascin-c for mortality of critical diseases and application of diagnostic biomarker tenassin-c

A technology of tenascin-c and mortality, which is applied in the field of diagnostic systems, can solve the problems of many items in real-time inspection results, increased human errors, and inaccuracy

Pending Publication Date: 2021-01-05
AFFILIATED HUSN HOSPITAL OF FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

While SOFA scores are generally reliable enough, variables that are calculated or strictly adhere to the data definition become less accurate when scoring
And so far, the SOFA score still relies on doctors to manually fill in the form for calculation, and there is no corresponding automatic data extraction and scoring program, which greatly increases the possibility of human error
Even if we reduce this human error by repeated checking or two-person comparison, SOFA scoring requires a lot of immediate inspection results, and it is difficult to get an accurate score of the day immediately.

Method used

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  • Diagnostic biomarker tenascin-c for mortality of critical diseases and application of diagnostic biomarker tenassin-c
  • Diagnostic biomarker tenascin-c for mortality of critical diseases and application of diagnostic biomarker tenassin-c
  • Diagnostic biomarker tenascin-c for mortality of critical diseases and application of diagnostic biomarker tenassin-c

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Example 1 Comparison of baseline levels between the critically ill group and normal control patients

[0046] The 46 patients who came to the hospital for physical examination were used as normal controls, and their serum and baseline indicators were also collected to compare the baseline levels of age, sex, weight, creatinine, platelets, SOFA scores, and serum TNC levels between the selected patients and the normal control group Is there a difference. The results showed that the average age of the control group was 54.67±5.83 years old, the average weight was 66.32±3.07Kg, and 54.35% were male. The age and weight of the study cohort did not meet the normal distribution. The median age was 56 years old (38 years old, 67 years old), the median weight was 63.0Kg (55.0Kg, 72.5Kg), and 65.67% were male. The median platelet level in the normal control group was 220.0×109 / L(153.0×10 9 / L, 310.0×10 9 / L), the study cohort was 157.0×10 9 / L(77.0×10 9 / L, 224.5×10 9 / L). ...

Embodiment 2

[0050] Example 2 Detection of Serum TNC Levels and Mortality in Critically Ill Patients

[0051] Among the 134 patients included in the study, there were 27 all-cause deaths at the end of the 28-day follow-up period, and the 28-day all-cause mortality rate was 20.15%. The patients were divided into four groups according to the TNC level of 0-133.0ng / ml, 133.0-491.8ng / ml, 491.8-850ng / ml and greater than 850ng / ml, and the survival curve was drawn. Comparing the age, gender and body weight of the four groups, there was no statistical difference between any two groups. The 28-day survival rates of the four groups were 92.57%, 82.23%, 66.94%, and 26.45%, respectively, with significant statistical differences. Higher TNC levels corresponded to higher mortality.

Embodiment 3

[0052] Example 3 Serum TNC level is moderately correlated with SOFA score

[0053] Spearman correlation analysis was performed on the SOFA score and serum TNC level of critically ill patients on the day of blood drawing, and the results showed that the correlation coefficient was 0.4486, P<0.0001, showing a moderate correlation in statistical significance. A linear fitting equation can be obtained: Y=53.03*X+168.3.

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Abstract

The invention belongs to the technical field of diagnostic reagents and systems, and relates to a diagnostic biomarker and application of the diagnostic biomarker in products for judging severity of critical diseases and predicting mortality. The invention particularly relates to application of tenascin-c (TNC) as a detection marker of critical disease mortality and in preparation of a critical disease mortality detection system and a kit thereof. Through experiments, results show that critically ill patients have higher creatinine level, SOFA score and serum TNC level than normal people, andthe higher the serum TNC level is, the higher the death rate is; the test efficiency of the TNC is similar to the SOFA score, the TNC level has good linear correlation with the SOFA score, and the TNChas clinical popularization value as a diagnostic biomarker.

Description

technical field [0001] The invention belongs to the field of diagnostic systems, and relates to a diagnostic biomarker and its application in the judgment of critical illness severity and mortality prediction. In particular, it relates to the use of tenascin-c (TNC) as a diagnostic biomarker in the preparation of a detection kit and detection system for the judgment of the severity of a critical illness and the prediction of mortality. Background technique [0002] Critical illness is seen in patients with unstable vital signs and rapid disease progression, often life-threatening. Many demographic and economic studies have shown that the social and economic burdens of critical illness in developed countries have far exceeded expectations, and are still increasing with the aging population. Early detection, diagnosis, and treatment of critically ill patients can not only improve the survival rate of patients, but also play a positive role in reducing the global economic burd...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/68
CPCG01N33/68
Inventor 郝传明谢琼虹尚达徐赟玙
Owner AFFILIATED HUSN HOSPITAL OF FUDAN UNIV
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