Microbiome related immunotherapies
A technology of microbial composition and fecal microorganisms, applied in the field of microbiome-related immunotherapy, can solve the problems of impact, anti-cancer therapy and harmful health
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Embodiment 1
[0490] Example 1: Use of fecal microbiota transplantation (FMT) to treat a 25-year-old male with metastatic melanoma unresponsive to immunotherapy.
[0491] In this example, human patients with metastatic melanoma underwent fecal microbiota transplantation (FMT) as adjuvant therapy with pembrolizumab.
[0492] The patient was a 25-year-old male with an initial diagnosis of malignant melanoma by excisional biopsy of an anal lesion. At that time, the lesion was 3.75 mm, ulcerated, suggestive of melanoma, with signs of superficial spread and suspicion of lymphovascular invasion. Biopsy slides were analyzed and confirmed as malignant melanoma (mucosal macule / pagetoid pattern, BRAF mutation, tumorigenic and mitogenic, Breslow thickness 3.7 mm, Clark IV), likely with lymphovascular invasion and There may be vascular invasion.
[0493] Since the patient had stage 4 melanoma, it was understandable from the start that his cancer had spread to other parts of his body, including his gr...
Embodiment 2
[0506] Example 2: Use of fecal microbiota transplantation (FMT) to treat chronic diarrhea in a 65-year-old man with refractory multiple myeloma.
[0507] In this example, a human patient with refractory multiple myeloma was treated with fecal microbiota transplantation (FMT) to help reduce his chemotherapy-induced chronic diarrhea.
[0508] The patient is a 65 year old male with multiple myeloma. To treat myeloma, the patient had previously been treated with the chemotherapy drugs fludarabine and Cytoxan, followed by an infusion of CAR-T cells. The patient's multiple myeloma status was considered highly refractory.
[0509] The patient had chronic diarrhea for more than a year due to a viral infection, which resulted in weight loss and muscle wasting. After chemotherapy, his diarrhea worsened substantially and significantly to the point where he released typically seven to eight liters of diarrhea per day for two weeks. As a result, the patient develops hypotension, electro...
Embodiment 3
[0514] Example 3: Treatment of pembrolizumab-induced colitis in a 71-year-old male cancer patient using fecal microbiota transplantation (FMT).
[0515] In this example, fecal microbiota transplantation (FMT) was administered to a human patient with a history of follicular lymphoma and gastric adenocarcinoma to help treat his pembrolizumab-induced colitis.
[0516] The patient was a 71-year-old male with a history of follicular lymphoma (diagnosed six years ago) and gastric adenocarcinoma (diagnosed three years ago). These cancers are treated with surgery and subsequent pembrolizumab treatment. After treatment with pembrolizumab, two sigmoidoscopies revealed severe colitis.
[0517] To treat colitis, patients were administered 250 ml of a liquid fecal microbiota composition prepared from the stools of healthy, disease-screened human donors via colonoscopy. After administration, the patient's colitis improved.
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