Nucleic acid analysis cartridges and nucleic acid analysis equipment

Abstract

The invention discloses a nucleic acid analysis cartridge and nucleic acid analysis equipment. The nucleic acid analysis cartridge includes a cartridge body and a magnetic bead transfer part movably arranged on the cartridge body along a set direction; the cartridge body is provided with a storage liquid cavity, sampling channel, exhaust channel and detection structure, there are at least two liquid storage chambers and they are distributed sequentially along the set direction; the magnetic bead transfer part is provided with a magnetic bead enrichment Both the channel and the detection structure are located on the same side of the magnetic bead transfer part, and the surface where the liquid storage chamber is located is in sealing connection with the magnetic bead transfer part, and the magnetic bead transfer part can make the magnetic bead enrichment structure communicate with each liquid storage chamber in turn. The above-mentioned nucleic acid analysis cartridge can fully integrate nucleic acid extraction and amplification detection based on the magnetic bead method, which improves the compactness of the nucleic acid analysis cartridge, reduces the volume of the nucleic acid analysis cartridge, and promotes the popularization of molecular diagnostic technology.

Description

Technical field [0001] The present invention relates to the field of in vitro diagnostic techniques, and more particularly to a nucleic acid analysis cartridge and a nucleic acid analysis device. Background technique [0002] In the field of diagnosis in vitro, molecular diagnosis is common technique. Specifically, molecular diagnosis is a diagnostic technique for clinical detection using nucleic acid or protein as a biomarker, providing judgment for disease prediction, diagnosis, prevention and treatment. Especially in the face of severe cases of various sudden infectious diseases, molecular diagnosis technology can provide rapid, accurate diagnosis, and most economically effective. [0003] At present, nucleic acid extraction techniques based on magnetic beads are common technologies for nucleic acid extraction, which requires cleavage solution, magnetic bead binding, cleaning liquid, eluent, etc., and supplemented with magnetic beads multi-step manipulate. Automated nucleic ac...

AI Technical Summary

Problems solved by technology

Automated nucleic acid extraction equipment often requires complex liquid manipulation components, magnetic bead manipulation components, and detection devices, resulting in a large volume of equipment, which is difficult to meet the needs of areas with backward medical infrastructure and on-site instant detection

[0004] In addition, the combination of automated nucleic acid extraction and amplification detection has the risk of interface cross-contamination

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