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Analyzer for three-dimensionally analyzing a medical sample by means of a light-field camera

A light field camera and analyzer technology, applied in the field of blood analyzers, can solve the problems of limited comparability in blood smear analysis and achieve high-resolution results

Pending Publication Date: 2021-01-15
SIEMENS HEALTHCARE DIAGNOSTICS INC
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Therefore, the comparability of blood smear analyzes is limited to regions, as good comparisons can only be made for images of cells that have been stained according to the same protocol

Method used

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  • Analyzer for three-dimensionally analyzing a medical sample by means of a light-field camera

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Embodiment Construction

[0198] As shown in Figure 1, an automated analyzer for analyzing cells in a sample includes an optical microscope (1) that includes a light source (4) for illuminating the sample (2) and a light source (4) for converging and focusing the light from the illuminated A converging lens for the light beam (6) emitted by the sample (2). The sample (2) is a blood sample containing blood cells (3). The sample (2) is located in the microfluidic flow cell (10). Furthermore, the microscope (1) comprises a light field camera (8) with a digital recording device comprising a CCD chip or a CMOS chip for acquiring the light field imaged in the microscope (1). Furthermore, the microscope (1) comprises a further camera for acquiring images in the object plane, which is realized as a high-resolution 3-chip color camera (9). The lateral resolution of the color camera (9) is four times the effective lateral resolution of the light field camera (8). The focus of the color camera (9) is set on th...

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Abstract

The invention relates to an analyzer for analyzing a medical sample. The analyzer comprises an optical microscope for imaging a light field in an object region in order to image the sample. The microscope comprises a light source for illuminating the sample, an objective comprising a converging lens for concentrating and focusing light beams coming from the illuminated sample, and a digital recording device for recording the light beams. A light-field camera for capturing the light field from the object region, which light field is imaged in the microscope, is provided on the microscope.

Description

technical field [0001] The invention belongs to the field of automatic analyzers, and relates to a blood analyzer for analyzing cells in a sample using a microscope device with a light field camera. Background technique [0002] So-called "automated cell counters" are used with increasing success for the automated analysis of cells. Examples of this are the Advia2120, Sysmex XE-2100, CellaVision DM96 and CellaVision DM1200 devices. In addition to their high throughput, these automated devices offer advantages such as a high degree of objectivity (does not vary across observers), eliminates statistical variations usually associated with manual counting (counting of large cell numbers), And it was determined that a number of parameters would not be available in the case of manual counting, and as mentioned above, automated equipment is a more efficient and cost-effective way of handling. Some of these devices can process 120 to 150 patient samples per hour. [0003] The tec...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G02B21/36G02B27/00G06K9/00
CPCG02B21/361G02B21/367G02B27/0075G06V20/69G06V2201/03G02B30/10H04N23/10G06T7/557G06T11/001G06T2207/10052G06T2207/10056G06T2207/30024G06V20/698H04N23/56H04N23/67H04N23/90H04N23/957
Inventor 托马斯·恩格尔加比·马夸特加布里埃莱·赫尼希卢卡斯·里克特
Owner SIEMENS HEALTHCARE DIAGNOSTICS INC