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A kind of external composition with healing effect and its preparation method and application

An external composition and efficacy technology, applied in the field of composition with healing effect and its preparation, can solve problems such as long wound healing time, new skin and wound damage, invasion, etc.

Active Publication Date: 2021-09-10
北京中康联健康科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] For the treatment of wounds, antibiotics or some anti-inflammatory drugs are generally used clinically to treat skin wounds. Although antibiotics can prevent infection and anti-inflammatory drugs can inhibit inflammation of wounds, there are certain toxic and side effects, especially when patients use these antibiotics for a long time Certain drug dependence and drug resistance will be produced after the class of drugs, and the curative effect is not significant
As a traditional medicine in my country, traditional Chinese medicine has a long history of trauma treatment. However, traditional Chinese medicine is mostly powder or ointment. When it is used to treat wounds, the wound healing takes a long time, and it needs to be changed regularly. Debridement will cause damage to the new skin and wound, and it will cause pain and other discomfort when changing the dressing. In addition, when the powder type therapeutic medicine is applied to the wound, the wound cannot be completely isolated from the outside world, which may easily cause bacteria, dust or water. invade and infect
[0004] In view of the related technologies mentioned above, the inventor believes that when patients use antibiotics to treat wounds for a long time, they are prone to drug dependence and drug resistance. wound infection

Method used

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  • A kind of external composition with healing effect and its preparation method and application
  • A kind of external composition with healing effect and its preparation method and application
  • A kind of external composition with healing effect and its preparation method and application

Examples

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Effect test

preparation example 1

[0044] Preparation Example 1: (1) Remove the viscera from the sea cucumber, wash it, and freeze it for 3 hours at a temperature of -25°C and a vacuum of 20 Pa; (2) Crush it after freezing, and add water 10 times its mass to the powder , to make sea cucumber slurry;

[0045] (3) Add the sea cucumber slurry into the colloid mill, grind for 30 minutes, take it out and place it at 700MPa and 50°C for sealed extraction for 3 times, 20 minutes each time, combine the extracts, use supercritical CO2 to extract the extracts, and obtain the extracts, supercritical Extraction pressure is 40MPa, add compound enzyme, enzymatic hydrolysis at 45°C for 6h, the amount of compound enzyme added is 0.2% of the weight of the extract, compound enzyme is prepared by pepsin, trypsin and collagenase in a mass ratio of 1:1:2 become;

[0046] (4) Add ethanol whose mass concentration is 80% to the extract, mix well and let it stand at 10°C for 24 hours, take the supernatant, concentrate under reduced pr...

preparation example 2

[0047] Preparation example 2: (1) remove the viscera of the sea cucumber, wash it, and freeze it for 2.5 hours at a temperature of -23°C and a vacuum of 15Pa;

[0048] (2) Pulverize after freezing, add water 10 times its mass to the powder to make sea cucumber slurry;

[0049] (3) Add the sea cucumber slurry into a colloid mill, grind for 25 minutes, take it out and place it at 750MPa and 55°C for sealed extraction twice, 25 minutes each time, combine the extracts, use supercritical CO2 to extract the extracts, and obtain the extracts, supercritical Extraction pressure is 43MPa, add compound enzyme, enzymatic hydrolysis at 55°C for 4h, the amount of compound enzyme added is 1.1% of the weight of the extract, compound enzyme is prepared by pepsin, trypsin and collagenase in a mass ratio of 1:1:2 become;

[0050] (4) Add ethanol whose mass concentration is 75% to the extract, mix evenly and let it stand at 15°C for 16 hours, take the supernatant, concentrate under reduced press...

preparation example 3

[0051] Preparation example 3: (1) remove the viscera of the sea cucumber, wash it, and freeze it for 2 hours at a temperature of -20°C and a vacuum of 10 Pa;

[0052] (2) Pulverize after freezing, add water 10 times its mass to the powder to make sea cucumber slurry;

[0053] (3) Add the sea cucumber slurry into the colloid mill, grind for 20 minutes, take it out and place it at 800MPa and 60°C for sealed extraction twice, 30 minutes each time, combine the extracts, use supercritical CO2 to extract the extracts, and obtain the extracts, supercritical Extraction pressure is 45MPa, add compound enzyme, enzymolysis at 60°C for 2 hours, the amount of compound enzyme added is 2% of the weight of the extract, compound enzyme is prepared by pepsin, trypsin and collagenase in a mass ratio of 1:1:2 become;

[0054] (4) Add 70% ethanol with a concentration twice its mass to the extract, mix well and let stand at 20°C for 8 hours, take the supernatant, concentrate under reduced pressure...

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Abstract

The application relates to the technical field of medical care products, and specifically discloses a composition with healing effect, its preparation method and application. Composition with healing properties comprising the following raw materials: water, glycerol acrylate / acrylic acid copolymer, PVM / MA copolymer, cactus thorn stem extract, tapioca starch, asiaticoside, polyacrylate crosspolymer‑ 6. Allantoin, humectant, preservative; the preparation method is: mix water, humectant, preservative, glycerin acrylate / acrylic acid copolymer and tapioca starch to obtain phase A; extract of cactus thorn stem, Mix asiaticoside, allantoin, polyacrylate cross-linked polymer-6 and PVM / MA copolymer to obtain phase B; mix phase B and phase A to make them homogeneous. The composition with wound healing effect of the present application can be used for photon cold gel, rolling ball cold compress gel, liquid callus spray water and medical cold compress patch, which has the advantages of promoting wound healing, antibacterial and antipruritic.

Description

technical field [0001] This application relates to the technical field of medical care products, more specifically, it relates to a composition with healing effect and its preparation method and application. Background technique [0002] Damage to normal skin tissue caused by external traumatic factors such as surgery, external force, heat, electric current, chemical substances, low temperature, and internal factors such as local blood supply disturbance is called wound. Trauma has become a common occurrence in daily life. Diseases and trauma patients are vulnerable to various bacteria due to the loss of the natural barrier of the skin and mucous membranes, leading to wound infection. Wound infection is a pathological reaction caused by pathogenic microorganisms invading the body through the wound, growing and multiplying in the body, causing damage to the normal function, metabolism and tissue structure of the body, and causing tissue damage. Wound infection is a difficult ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7024A61K36/33A61K38/01A61K9/06A61K9/70A61K47/32A61K47/36A61K47/10C12P21/06C07K1/14C07K1/30A61K31/4166A61K31/047A61K31/7016A61K36/87A61K36/8962A61K31/727
CPCA61K9/0014A61K9/06A61K9/12A61K9/7023A61K31/047A61K31/4166A61K31/7016A61K31/7024A61K31/727A61K36/33A61K36/60A61K36/73A61K36/74A61K36/81A61K36/87A61K36/8962A61K38/012A61K47/10A61K47/18A61K47/32A61K47/36A61K2236/19A61K2236/31A61P17/02A61P17/04C07K1/145C07K1/30C12P21/06A61K2300/00Y02P20/54
Inventor 万擎王建华孔义博安平平
Owner 北京中康联健康科技有限公司
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