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Application of Mycophenolic Acid in Treatment and Prevention of Coxsackie Virus Infection

A technology of coxsackie virus and mycophenolic acid, applied in antiviral agents, medical preparations containing active ingredients, pharmaceutical formulas, etc., can solve problems such as the absence of enteroviruses

Active Publication Date: 2022-03-29
BEIJING UNIV OF CHEM TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

CV-A9 is considered to be one of the important pathogens of viral encephalitis, but there is no specific drug against enterovirus

Method used

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  • Application of Mycophenolic Acid in Treatment and Prevention of Coxsackie Virus Infection
  • Application of Mycophenolic Acid in Treatment and Prevention of Coxsackie Virus Infection
  • Application of Mycophenolic Acid in Treatment and Prevention of Coxsackie Virus Infection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Example 1. Exploring the anti-Coxsackie virus activity of mycophenolic acid

[0046] 1. Experimental method

[0047] 1. Cell culture and virus culture

[0048] The human renal epithelial cell line 293T was obtained from the American Type Culture Collection (ATCC, CRL-3216TM) at 37°C, 5% CO 2 cultured in DMEM medium (Gibco) containing 10% fetal bovine serum (FBS; Gibco Invitrogen) under the condition of .

[0049] Coxsackievirus A type 9 strain BUCT01 was propagated in 293T cells, and RD cells (ATCCCCL-136) were used for plaque assay to determine the virus titer. All infection experiments were performed in a biosafety level 2 (BLS2) laboratory.

[0050] The listed drug library (product number L1000, including 2080 kinds of drugs already on the market) is a product of Shanghai Taosu Biochemical Technology Co., Ltd. The initial concentration of all drugs was 10 mM (millimole per liter).

[0051] 2. Explore whether B2M or FcRn is the receptor of CV-A9 infected cells

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Abstract

The invention discloses the application of mycophenolic acid in the treatment and prevention of coxsackie virus infection. The present invention provides the use of mycophenolic acid or a derivative thereof or a pharmaceutically acceptable salt thereof or a substance using mycophenolic acid or a derivative thereof or a pharmaceutically acceptable salt thereof as an active ingredient in any of the following: inhibiting Coxsackie virus, treatment and / or prevention of disease due to coxsackie virus infection, improvement of symptoms due to coxsackie virus infection. According to the invention, mycophenolic acid, an active drug against Coxsackie virus, is screened out from antiviral drugs based on the Coxsackie virus drug screening model. The invention has important clinical application value for the treatment and prevention of diseases after infection with Coxsackie virus.

Description

technical field [0001] The invention relates to the field of medicine, in particular to the application of mycophenolic acid in the treatment and prevention of Coxsackie virus infection. Background technique [0002] Coxsackievirus (Coxsackievirus) is an enterovirus (enterovirus), which belongs to the Picornaviridae family and the genus Enterovirus. Its biological properties are similar to those of poliovirus, the diameter of the virion is 28nm, there is no envelope structure and the nucleic acid is single positive strand RNA. Coxsackie virus is a common virus that infects the human body through the respiratory tract and digestive tract. After infection, people will have cold symptoms such as fever, sneezing, and coughing. In severe cases, it can cause aseptic meningitis. According to the observation of pathogenicity in the early stage of neonatal mouse infection virus, Coxsackie virus can be divided into two types: A and B, of which type A is more common in children, tends...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/5377A61P31/14
CPCA61K31/5377A61P31/14
Inventor 范华昊童贻刚刘玉洁宋立华安小平贺哓琪娄福星陈杨桢韩可刘文丽王立钦胡运甲
Owner BEIJING UNIV OF CHEM TECH