Application of 4-diethylaminosalicylaldehyde nicotinylhydrazone in the preparation of molecular probes, molecular probes and their preparation methods and applications

Abstract

The invention discloses the application of 4‑diethylamino salicylaldehyde nicotinyl hydrazone in the preparation of molecular probes, the molecular probe and its preparation method and application. The preparation method of the molecular probe is to use 4‑(diethylamino ) salicylaldehyde and nicotinic acid hydrazide are reacted as raw materials to obtain SBN, the molecular probe. The preparation method of the molecular probe of the present invention does not need to use a catalyst, does not need to be heated and refluxed, and can be carried out at normal temperature and pressure. Molecular probe of the present invention is to Al 3+ It shows two fluorescence response signals and one UV absorption response signal, can be used as a fluorescent probe and a UV probe at the same time, has excellent ion selectivity and anti-interference ability, good water solubility, and low detection limit.

Description

technical field [0001] The invention relates to the technical field of fluorescent probes, in particular to the application of 4-diethylaminosalicylaldehyde nicotinyl hydrazone in the preparation of molecular probes, molecular probes and their preparation methods and applications. Background technique [0002] The content of aluminum in the earth's crust is second only to oxygen and silicon, and it is the most abundant metal element. With the development of aluminum smelting technology, it plays an increasingly important role in the fields of construction, aerospace, transportation, and domestic water purification. , the output of aluminum is increasing year by year, and it has also aroused social concern about aluminum pollution. [0003] On October 27, 2017, the list of carcinogens released by the International Agency for Research on Cancer of the World Health Organization was initially compiled for reference, and aluminum products were included in the list of first-class ...

AI Technical Summary

Problems solved by technology

[0004] In recent years, many studies have reported the detection methods of aluminum ions, such as atomic emission spectrometry, titration, electrochemical methods, ion chromatography, etc., but these methods generally require expensive detection instruments, complicated sample preparation, damage to cell structure, However, the fluorescent probe method, which can realize real-time in-situ detection, good selectivity, and simple operation, has the disadvantages of poor anti-interference, insufficient selectivity, high detection limit, and high concentration. Fluorescence Quenching (ACQ) Problems

For example, it has been reported that 3-aminopyrazinylhydrazone derivatives can be used as fluorescent probes for detecting aluminum ions, but the fluorescent probes can only be synthesized under the action of a catalyst, and the preparation process requires heating and reflux, making the preparation method complicated.

The fluorescent probe of 3-aminopyrazinylhydrazone derivatives not only has a fluorescent response to aluminum ions, but also emits a certain intensity of fluorescence in zinc ion solution, which is insufficient in selectivity; at the same time, the fluorescent probe of 3-aminopyrazinylhydrazone derivatives The detection for aluminum ion is 3.38×10 -8 mol / L, it cannot be detected for lower concentrations of aluminum ions; in addition, the fluorescent probe of 3-aminopyrazinylhydrazone derivatives can only be detected in pure organic solvents or organic solvent aqueous solutions, and it is difficult to detect them in pure water environments detection, limits its application

Images