Application of biomarker for detecting intracranial aneurysm, expression method and kit

Abstract

The invention belongs to the technical field of biomarkers, and discloses an application of a biomarker for detecting intracranial aneurysm, an expression method and a kit. The biomarker for detectingintracranial aneurysm is CD11a; the biomarker CD11a is a protein coded by a parent gene ITGAL corresponding to has_circ_0000690; the expression method of the biomarker for detecting intracranial aneurysm comprises the following steps: collecting a specimen; extracting total RNA; detecting the expression level of mRNA and CD11a of the has_circ_0000690 and the ITGAL in ICA patients and peripheral blood of a normal person; searching the biomarker for diagnosing intracranial aneurysm; and performing statistical analysis. According to the invention, the expression difference between the has_circ_0000690 in the peripheral blood of the ICA patients and the has_circ_0000690 in the peripheral blood of the normal person is defined, the possibility of the has_circ_0000690 as a non-invasive biomarkeris explored, and the has_circ_0000690 has strong innovativeness.

Description

Technical field[0001]The invention belongs to the technical field of biological markers, and in particular relates to a use, expression method and kit of biological markers for detecting intracranial aneurysms.Background technique[0002]At present, intracranial aneurysm (ICA) is characterized by pathological saccular expansion and protrusion of cerebral blood vessels. In cerebrovascular accidents, ICA is second only to cerebral infarction and hypertensive cerebral hemorrhage, ranking third, but its The risk of surgery, postoperative disability, and mortality are much higher than cerebral infarction and hypertensive cerebral hemorrhage. At present, the diagnosis, condition and prognosis assessment of ICA mainly rely on imaging, hemodynamics and the construction of biological models. As the gold standard for diagnosing ICA, DSA is an invasive examination, which is expensive and requires hospitalization. The process is cumbersome and is not suitable for extensive screening by the genera...

AI Technical Summary

Problems solved by technology

[0019] (1) DSA is an invasive test with high cost and requires hospitalization. The process is cumbersome and not suitable for extensive screening of the general population.

Hemodynamic examination, the process is complicated, the accuracy of the results is not high, special equipment is required, and it is difficult to carry out widely

[0020] (2) The death and disability rate of intracranial aneurysm is high, and the current early diagnosis and screening methods are not ideal

[0021] (3) At present, there is no molecular marker that can quickly and conveniently detect intracranial aneurysms with certain clinical value

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