Hydrogel active dressing with antibacterial and anti-inflammatory functions

Abstract

The invention provides a hydrogel active dressing with antibacterial and anti-inflammatory functions, and belongs to the field of medical hydrogel dressings. The dressing is prepared by the followingsteps: taking 2-vinyl-4, 6-diamino-1, 3, 5-triazine and hydroxyethyl acrylate as monomers, preparing a linear copolymer by adopting a chemical polymerization method, blending with amyloid protein fibers, generating a loose cross-linked network under the action of a cross-linking agent to form a first gel product, introducing a mixture of carboxymethyl chitosan and a water-soluble polyphenol compound into the loose first gel product, performing freeze-thaw cycle treatment under the combined action of the cross-linking agent in the first gel product, and performing secondary gelation to form cross-linked hydrogel which is mainly subjected to physical cross-linking and is assisted by chemical cross-linking. The mechanical property of the hydrogel dressing is greatly improved, and the hydrogeldressing has good antibacterial, anti-inflammatory and self-recovery functions and is suitable for wound protection and treatment of burns, scalds and traumatic wounds.

Description

technical field [0001] The invention relates to the field of medical hydrogel dressings, in particular to a hydrogel active dressing with antibacterial and anti-inflammatory functions. Background technique [0002] Medical dressings are wound coverings, which replace the damaged skin to play a temporary barrier role in the wound healing process and provide an environment conducive to wound healing. During the wound healing process, the damaged skin is easily infected by bacteria, leading to wound deterioration, Melting veins, and even death of the patient. Therefore, it is very important that medical dressings have good antibacterial properties. [0003] Hydrogel dressing is a new type of wound dressing developed in recent years. It is mainly composed of a gelatinous substance with a three-dimensional network structure formed after the polymer absorbs water and swells. It has a high water content and can keep the wound partially moist. The environment, while absorbing tiss...

AI Technical Summary

Problems solved by technology

In order to ensure its antibacterial performance, people try to assemble different antibiotics into hydrogel dressings, but the long-term application of antibiotics at the infection site will cause bacterial resistance and produce toxic side effects. On the other hand, hydrogels usually It exhibits poor mechanical properties, so it is necessary to develop a hydrogel dressing that does not contain antibiotics, has antibacterial and anti-inflammatory functions, and has good mechanical properties and biocompatibility

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