Application of Remimazolam in the Preparation of Drugs for Treating Opioid-Induced Postoperative Hyperalgesia

A technology of hyperalgesia and remimazolam, applied in the field of biomedicine, can solve problems affecting the quality of life of patients, occupying medical resources, and reducing the analgesic effect of drugs

Active Publication Date: 2022-02-25
李依泽 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

RIH not only reduces the analgesic effect of drugs, but also promotes pain perception, produces abnormal pain, and even causes postoperative chronic pain. The most important thing is to increase the physical and mental trauma of patients, aggravate the pain of patients, and seriously affect the quality of life of patients
At present, there is no effective clinical treatment, mainly because its mechanism is still unclear. Therefore, it is urgent to clarify the pathogenesis of remifentanil-induced hyperalgesia and find effective treatment strategies

Method used

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  • Application of Remimazolam in the Preparation of Drugs for Treating Opioid-Induced Postoperative Hyperalgesia
  • Application of Remimazolam in the Preparation of Drugs for Treating Opioid-Induced Postoperative Hyperalgesia
  • Application of Remimazolam in the Preparation of Drugs for Treating Opioid-Induced Postoperative Hyperalgesia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Example 1 Effect of remimazolam on opioid-induced incision hyperalgesia

[0038] 1. Experimental grouping: 42 male SD rats, 1 month old, weighing 100-120 g, were purchased from the Experimental Animal Center of the Academy of Military Medical Sciences of the Chinese People's Liberation Army. Divided into 7 groups (n=6) by random number table method:

[0039] In the normal saline group (NS group), infuse the same volume of normal saline with remifentanil through the tail vein for 60 minutes;

[0040]Remifentanil + incisional pain group (RI group), infusion of remifentanil (batch number: A010919, Yichang Humanwell Pharmaceutical Co., Ltd.) 1 μg kg via tail vein -1 min -1 A total of 60 minutes, while establishing the incision pain model;

[0041] Remimazolam 1 (batch number: Jiangsu Hengrui Medicine Co., Ltd.) + remifentanil + incisional pain group (R1RI group) infusion of remimazolam 1 mg kg via tail vein -1 h -1 , remifentanil 1 μg kg -1 min -1 A total of 60 minut...

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Abstract

The invention relates to the application of remimazolam in treating postoperative hyperalgesia induced by opioids. The present invention proves that remimazolam can inhibit postoperative hyperalgesia induced by remifentanil by promoting the expression of GABAa receptor. The research results of the present invention provide a novel treatment approach for hyperalgesia caused by opioids, and have good clinical application prospects.

Description

technical field [0001] The invention belongs to the field of biomedicine, and relates to the application of remimazolam in treating postoperative hyperalgesia induced by opioids. Background technique [0002] Opioids are the most important analgesic drugs for the clinical treatment of acute and chronic pain and cancer pain, and the clinical dosage is huge, but they can also activate the pro-nociceptive mechanism in the body while analgesic, which is manifested by the body's response to nociceptive Stimulus responsiveness increases, and the demand for analgesic drugs increases, that is, opioid-induced hyperalgesia (OIH). Remifentanil is an ultra-short-acting μ-opioid receptor agonist, which is widely used in clinical intraoperative analgesia due to its advantages of fast onset, fast clearance, no accumulation, and metabolism independent of liver and kidney function. However, the incidence of remifentanil-induced postoperative hyperalgesia (RIH) is much higher than that of ot...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/5517A61P25/00
CPCA61K31/5517A61P25/00
Inventor 李依泽张麟临于泳浩王国林李晶丁冉董贝贝陈怡
Owner 李依泽
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