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Medicinal preparation for external use

A composition and active ingredient technology, applied in the direction of medical preparations containing active ingredients, anti-inflammatory agents, pharmaceutical formulations, etc., can solve the problems of undisclosed pharmacokinetic effects

Pending Publication Date: 2021-02-26
SUMITOMO DAINIPPON PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] However, Patent Document 1 only discloses in vitro studies for evaluating effects on Na channels, and it does not disclose any considerations about pharmacokinetic effects, including percutaneous absorption

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0066] 1% by weight of Compound A was added to 7% by weight of oleic acid, and the mixture was mixed until dissolved. 92% by weight of white petrolatum was added thereto, and the mixture was uniformly mixed and kneaded to form an ointment preparation.

Embodiment 2

[0068] 1% by weight of Compound A was added to 7% by weight of oleic acid, and the mixture was mixed until dissolved. 91% by weight of white petrolatum and 1% by weight of water for injection were added thereto, and the mixture was uniformly mixed and kneaded to form an ointment preparation.

Embodiment 3

[0070] 1% by weight of Compound A was added to 7% by weight of oleic acid, and the mixture was mixed until dissolved. 89% by weight of white petrolatum and 3% by weight of water for injection were added thereto, and the mixture was uniformly mixed and kneaded to form an ointment preparation.

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PUM

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Abstract

The present invention pertains to a drug for the treatment and / or prevention of pain, more specifically to a medicinal preparation for external use to treat and / or prevent peripheral neuropathic pain,the medicinal preparation containing as an active ingredient N2-{[1-ethyl-6-(4-methylphenoxy)-1H-benzimidazol-2-yl]methyl}-L-alaninamide.

Description

technical field [0001] The present invention relates to a medicament for the treatment and / or prevention of pain, more particularly to a medical preparation for external use in the treatment and / or prevention of peripheral neuropathic pain, comprising N 2 -{[1-Ethyl-6-(4-methylphenoxy)-1H-benzimidazol-2-yl]methyl}-L-alaninamide as active ingredient. Background technique [0002] Peripheral nerve pain is a serious symptom in many diseases and, depending on the degree, can have a significant impact on a person's quality of life and can interfere with many kinds of general human function. [0003] It is known that the mechanism by which peripheral nerve pain is sensed is that a signal of pain is transmitted from peripheral sensory nerves to the brain via the spinal cord, thereby generating pain sensation. Sodium channels are also known to be involved at several points of action in the pathway, and different types of sodium channels are involved depending on the point of action...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4184A61K9/06A61K9/12A61K9/70A61P25/02A61P29/02
CPCA61P29/02A61P25/02A61K9/06A61K31/4184A61K47/06A61K9/0014A61K9/7061A61K9/7053A61K9/12A61K9/70
Inventor 田中雅康小山田义博高田宜则
Owner SUMITOMO DAINIPPON PHARMA CO LTD