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Application of substance for detecting oral bacteria to diagnosis of gestational diabetes mellitus

A technology for gestational diabetes and bacteria, applied in the field of biomedicine, can solve the problems of time-consuming, difficult clinical detection, etc., and achieve the effect of convenient sampling

Pending Publication Date: 2021-03-05
INST OF ZOOLOGY CHINESE ACAD OF SCI
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

However, this method is invasive and time-consuming, and requires multiple collections of pregnant women’s blood, which is not easy for clinical detection. Therefore, it is urgent to find an effective method that is convenient for sampling, takes a short time for sampling, is non-invasive to patients, and can be operated at any time to assist the disease. Diagnostics and Routine Testing

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  • Application of substance for detecting oral bacteria to diagnosis of gestational diabetes mellitus
  • Application of substance for detecting oral bacteria to diagnosis of gestational diabetes mellitus
  • Application of substance for detecting oral bacteria to diagnosis of gestational diabetes mellitus

Examples

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Embodiment 1

[0040] Example 1, markers for diagnosing gestational diabetes in pregnant women

[0041] This study was approved by the Ethics Committee of Wenzhou People's Hospital. Pregnant women who were treated in Wenzhou People's Hospital were recruited, and the subjects and their families gave informed consent.

[0042] Objects to be tested: 67 pregnant women without gestational diabetes (selected into the healthy group) and 44 pregnant women with gestational diabetes (selected into the patient group).

[0043] The inclusion criteria for the healthy group (GDM-) are: pregnant women between the ages of 25 and 35, who are not suffering from GDM as determined by a professional doctor based on the results of the OGTT. The OGTT test is carried out during the 24th to 28th week of pregnancy. The operation method is as follows: 1) Eat a normal diet 3 days before blood collection, and fast for 8-14 hours from 21:00 the night before blood collection. 2) On the day of blood collection, draw blood...

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Abstract

The invention discloses an application of a substance for detecting oral bacteria to diagnosis of gestational diabetes mellitus. The substance for detecting the oral bacteria disclosed by the invention is a substance for detecting Streptococcus, Veillonella, Lautropia and / or Neisseria in saliva and / or dental plaque. According to the invention, the inventor finds that the Streptococcus, the Veillonella, the Lautropia and / or the Neisseria in the oral cavity can be used for detecting the gestational diabetes mellitus, and the accuracy can reach 74.41%-82.72% (P< 0.05 and FDR<0.1). The sampling for judging the gestational diabetes mellitus by utilizing microorganisms in the oral cavity is convenient, rapid and safe, and has non-invasiveness, and the substance can be used as an effective tool for auxiliary diagnosis, detection and prevention of the gestational diabetes mellitus in clinical and daily pregnancy health care.

Description

technical field [0001] The invention relates to the application of a substance for detecting oral bacteria in the diagnosis of gestational diabetes in the field of biomedicine. Background technique [0002] Gestational diabetes mellitus (GDM) is a disease of varying degrees of glucose intolerance that occurs for the first time during pregnancy. It is a common complication in the second and third trimesters of pregnancy and has been identified as an independent special type of diabetes. According to statistics, about 5.2% to 8.8% of pregnant women in the world develop GDM every year. The current incidence rate in China is 1.31-3.75%, but its incidence rate is increasing year by year. For the mother, GDM can cause ketoacidosis, pregnancy-induced hypertension syndrome, fetal malformation, macrosomia, stillbirth, infection, polyhydramnios, premature labor and dystocia; while for the offspring, GDM may cause neonatal respiratory distress syndrome Short-term complications such a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/6883C12Q1/689C12Q1/6869C12Q1/14C12Q1/04
CPCC12Q1/6883C12Q1/689C12Q1/6869C12Q2531/113C12Q2535/122C12Q2537/165
Inventor 王金锋赵方庆
Owner INST OF ZOOLOGY CHINESE ACAD OF SCI
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