Solution bath near-field cell 3D printing forming device and forming method thereof

A 3D printing and molding device technology, applied in the field of cell 3D printing, can solve the problems of low precision and low cell viability, and achieve the effects of improving accuracy, high cell density and saving costs

Pending Publication Date: 2021-03-12
FUJIAN INST OF RES ON THE STRUCTURE OF MATTER CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In order to improve various problems such as low precision and low cell survival rate in the current cell 3D printing technology, the present invention provides a solution bath near-field cell 3D printing forming device and its forming method

Method used

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  • Solution bath near-field cell 3D printing forming device and forming method thereof
  • Solution bath near-field cell 3D printing forming device and forming method thereof
  • Solution bath near-field cell 3D printing forming device and forming method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0054] like figure 1 The solution bath near-field cell 3D printing forming mechanism shown includes a 3D printing support platform 1-1, a 3D printing motion mechanism 1-2, an extrusion-control module 1-3, a cell ink holding chamber 1-4, and a low-pressure near-field cell 3D printing mechanism. Field modules 1-5, print nozzles 1-6 and solution bath collection modules. The solution bath collection module includes an insulating container 1-7, a conductive electrolyte solution 1-9 placed in the insulating container 1-7, and a lifting deposition platform 1-8 immersed in the conductive electrolyte solution 1-9.

[0055] The 3D printing movement mechanism 1-2 adopts the gantry type 3D printing mechanism, such as figure 2 As shown, it includes a linear motion module, a rotary motion module, and a control mechanism respectively connected to the linear motion module and the rotary motion module. The linear motion module and the rotary motion module are respectively connected to extrus...

Embodiment 2

[0063] The difference from Example 1 is that there are multiple print nozzles, and a nozzle temperature adjustment module is installed on the multiple print nozzles to realize the adjustment from -10°C to 260°C to meet the printing requirements of different cells.

Embodiment 3

[0065] The difference from Example 1 is that the print nozzle is a multi-nozzle structure, and the nozzle is divided into two types: one nozzle is used to print cells and their cell culture substrates, and can print multiple different cells; the other nozzle is used to print Print brackets. The same as in Embodiment 1, the structure of the print head is the same as the coaxial print head, and the inner channel and the outer channel can print different cell inks.

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Abstract

The invention discloses a solution bath near-field cell 3D printing forming device and a forming method thereof. The device comprises a near-field module, an extrusion-control module and a solution bath collection module, wherein the extrusion-control module is arranged above the solution bath collection module; the near-field module is arranged between the extrusion-control module and the solution bath collection module and is connected with the extrusion-control module and the solution bath collection module; and the solution bath collection module comprises an insulating vessel, an electrolyte solution contained within the insulating vessel and a deposition platform immersed into the electrolyte solution. During printing, filamentous cell ink is accurately printed onto the deposition platform and falls onto the deposition platform under the action of the electrolyte solution to be quickly gelled. The ink fineness of the device can reach 10 nanometers to 100 micrometers, and the printing precision can reach 10 micrometers; and meanwhile, the limitation of the viscosity of ink is avoided, and high-precision, high-freedom-degree and high-cell-activity cell 3D printing is achieved.

Description

technical field [0001] The invention belongs to the technical field of cell 3D printing, and in particular relates to a solution bath near-field cell 3D printing forming device and a forming method thereof. Background technique [0002] The structural units in the human body that are composed of various tissues and can perform certain or specific functions are called organs. Diseases, congenital deformities and traffic accidents have caused a large number of tissue and organ defects, which has also created a huge demand for tissue and organ repair in society. According to different sources of restorations, tissue and organ restorations can be divided into biological restorations and artificial restorations. Biological restorations can be divided into three types: allogeneic restorations, allogeneic restorations, and heterogeneous restorations. Allogeneic prosthesis obtains the transplant donor from the patient's own body, and its greatest advantage is that it can avoid imm...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B29C64/106B29C64/194B33Y30/00B33Y40/00
CPCB29L2031/7532B33Y30/00B33Y40/00B29C64/106B29C64/194
Inventor 林锦新许泽亚赵超前陈燕黄婷婷卢衍锦
Owner FUJIAN INST OF RES ON THE STRUCTURE OF MATTER CHINESE ACAD OF SCI
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