Synthetic method of diselenide compound

Abstract

The invention relates to a synthetic method of a diselenide compound, which comprises the following steps: putting arylboronic acid or derivatives thereof, elemental selenium, trimethylsilyl cyanide and an organic solvent into a reaction container to obtain a mixed solution, heating the mixed solution to 110-140 DEG C, stirring and reacting at the temperature for 18-30 hours to obtain a reaction solution, and carrying out aftertreatment to obtain a diselenide compound, wherein the ratio of the arylboronic acid or the derivative of the arylboronic acid to the elemental selenium to the trimethylsilyl cyanide is (6-10): (9-11): 1, wherein the dosage of the organic solvent is 4-6ml / mmol based on the molar weight of the arylboronic acid or the derivative thereof. The method has the following beneficial effects: 1, elemental selenium is adopted to replace a metal catalyst, metal is not needed for catalytic reaction, and the product is relatively environment-friendly; 2, the reaction conditions are mild, and the functional group tolerance is good; 3, a non-aryl phenol compound is used, so that the method is relatively environment-friendly; and 4, the yield is high.

Description

technical field [0001] The invention belongs to the field of organic chemistry, and in particular relates to a method for synthesizing diselenide compounds. Background technique [0002] Organic diselenide compounds have great application value. These compounds can be used as a class of very useful intermediates in synthesis, and can be used to synthesize a series of products with very application value such as monoselenides. It is widely used in the synthesis of biomolecules, the preparation of new materials, and the synthesis of drug molecules. Especially in animal model systems, this type of compound acts as a chemical protective agent as a whole to fight against various chemical carcinogens. thing. [0003] However, the current synthesis methods of diselenide compounds have the following disadvantages: 1. Most of the synthesis methods require metal catalysis, and the by-products are not environmentally friendly; 2. Most of the synthesis methods use Grignard reagents, wh...

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Problems solved by technology

[0003] However, the current synthesis methods of diselenide compounds have the following disadvantages: 1. Most of the synthesis methods require metal catalysis, and the by-products are not environmentally friendly; 2. Most of the synthesis methods use Grignard reagents, which require harsh conditions and functional groups Poor tolerance; 3. Most of the synthetic methods use aryl selenol compounds, which are not environmentally friendly; 4. Most of the synthetic methods have low yields

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