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Polysaccharide magnetic biochar nanoparticles as well as preparation method and application thereof

A magnetic nanometer and nanoparticle technology, which can be used in drug combinations, pharmaceutical formulations, allergic diseases, etc., can solve problems such as poor affinity, and achieve the effect of improving immune-enhancing activity.

Pending Publication Date: 2021-03-19
河南精检生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the poor affinity between organic and inorganic substances, it is a difficult task to uniformly disperse magnetic particles in polymer particles.

Method used

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  • Polysaccharide magnetic biochar nanoparticles as well as preparation method and application thereof
  • Polysaccharide magnetic biochar nanoparticles as well as preparation method and application thereof
  • Polysaccharide magnetic biochar nanoparticles as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] A preparation method of polysaccharide magnetic nano biochar particles, comprising the following steps:

[0038] S1, add 10mgFe 3 o 4 The magnetic particles were added to 50ml of polyethyleneimine PEI solution with a concentration of 0.1mg / mL and subjected to ultrasonic reaction to form polyethyleneimine PEI-modified Fe 3 o 4 Magnetic particle Fe 3 o 4 @PEI;Fe 3 o 4 The magnetic particles are prepared by conventional solvothermal synthesis, and the Fe 3 o 4 The surface of the magnetic particles is negatively charged, and the particle size range is 50nm; the molecular weight of polyethyleneimine PEI is 4000;

[0039] S2. Preparation of carboxylated biochar nanoparticles cNDs with a particle size of 50 nm:

[0040] S21, placing 10 g of biochar in a muffle furnace, and annealing at 425° C. for 4 hours to obtain nano-biochar powder;

[0041] S22. Disperse the annealed nano-biochar powder in a strong oxidizing mixed acid solution, and ultrasonically disperse it for...

Embodiment 2

[0052] A preparation method of polysaccharide magnetic nano biochar particles, comprising the following steps:

[0053] S1, add 10mgFe 3 o 4 The magnetic particles were added to 50ml of polyethyleneimine PEI solution with a concentration of 10mg / mL and subjected to ultrasonic reaction to form polyethyleneimine PEI-modified Fe 3 o 4 Magnetic particle Fe 3 o 4 @PEI;Fe 3 o 4 The magnetic particles are prepared by conventional solvothermal synthesis, and the Fe 3 o 4 The surface of the magnetic particles is negatively charged, and the particle size range is 200nm; the molecular weight of polyethyleneimine PEI is 130000;

[0054] S2. Preparation of carboxylated biochar nanoparticles cNDs with a particle size of 200nm:

[0055] S21, placing 10 g of biochar in a muffle furnace, and annealing at 425° C. for 4 hours to obtain nano-biochar powder;

[0056] S22. Disperse the annealed nano-biochar powder in a strong oxidizing mixed acid solution, and ultrasonically disperse it f...

Embodiment 3

[0067] A preparation method of polysaccharide magnetic nano biochar particles, comprising the following steps:

[0068] S1, add 10mgFe 3 o 4 Magnetic particles were added to 50ml of polyethyleneimine PEI solution with a concentration of 2mg / mL, and subjected to ultrasonic reaction to form polyethyleneimine PEI-modified Fe 3 o 4 Magnetic particle Fe 3 o 4 @PEI;Fe 3 o 4 The magnetic particles are prepared by conventional solvothermal synthesis, and the Fe 3 o 4 The surface of the magnetic particles is negatively charged, and the particle size range is 100nm; the molecular weight of polyethyleneimine PEI is 110000;

[0069] S2. Preparation of carboxylated biochar nanoparticles cNDs with a particle size of 100 nm:

[0070] S21, placing 10 g of biochar in a muffle furnace, and annealing at 425° C. for 4 hours to obtain nano-biochar powder;

[0071] S22. Disperse the annealed nano-biochar powder in a strong oxidizing mixed acid solution, and ultrasonically disperse it for ...

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Abstract

The invention discloses a preparation method and application of polysaccharide magnetic biochar nanoparticles. The method comprises the following steps of modifying Fe3O4 magnetic nanoparticles with polyethyleneimine, and adsorbing a layer of carboxylated biochar to form a magnetic compound Fe3O4@cNDs of a biochar shell; and then adsorbing gynura divaricata polysaccharide nanoparticles prepared bya W / OW method by using the magnetic compound Fe3O4@cNDs to prepare the polysaccharide magnetic biochar nanoparticles. According to a magnetic composite nanomaterial, Fe3O4 particles of 100-500 nm areused as a magnetic core to provide strong magnetic responsiveness and superparamagnetism, and the polysaccharide nanoparticles prepared by the W / O / W method are adsorbed by the magnetic biochar compound Fe3O4@cNDs; and the polysaccharide magnetic biochar nanoparticles prepared by the method are convenient to prepare and easy to collect, have relatively good stability and strong immunopotentiationactivity, and significantly improve the immunopotentiation activity of polysaccharides.

Description

technical field [0001] The invention relates to the field of biochemical materials, in particular to a polysaccharide magnetic nano biochar particle and a preparation method and application thereof. Background technique [0002] Superparamagnetic nanoparticles have attracted the attention of the material community for their unique grain size and magnetic properties. In recent years, studies on iron-based superparamagnetic nanoparticles have shown that when Fe 3 o 4 Nanoparticles with a particle size between 5-100 nm will have superparamagnetic properties [Nanomaterials and Nanostructures (Second Edition), Science Press, 2001]. Since the size of iron-based superparamagnetic nanoparticles is much smaller than that of various cells in the body, it is possible to apply them in the field of biomedical materials such as highly sensitive clinical diagnosis or therapeutic reagents, and it provides a possibility for precision medicine. new research avenues. Under biomedical condi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/51A61K47/02A61K47/34A61K31/715A61P37/04
CPCA61K9/5115A61K9/5146A61K31/715A61P37/04
Inventor 李向辉郭振环马霞邱荣超田永平刘永录田香马浩强
Owner 河南精检生物科技有限公司
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