Compositions and methods for improvement of iron metabolism and gut microbiome health

A composition and microbial technology, applied in drug combination, pharmaceutical formulation, food science, etc., can solve problems such as iron deficiency and treatment non-response

Pending Publication Date: 2021-03-19
SIDERO BIOSCI LLC
View PDF1 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Additionally, many (indeed most) patients with iron deficiency do not respond to oral iron therapy, rendering them iron deficient

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Compositions and methods for improvement of iron metabolism and gut microbiome health
  • Compositions and methods for improvement of iron metabolism and gut microbiome health
  • Compositions and methods for improvement of iron metabolism and gut microbiome health

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0227] Figure 4 The experimental protocol is exemplified in . Figure 5 The study schedule is displayed in . Subjects were pre-screened and only non-anemic patients (hemoglobin >8 g / dL) were selected to participate in the study. All subjects were instructed to stop taking iron supplements and / or iron-containing multivitamins, if available, four weeks prior to study initiation.

[0228] Thirty-four subjects (demographics reported in Table 1) suffering from iron deficiency (transferrin saturation (TSAT) <20% and serum ferritin <50 ng / mL) were instructed to take 1.5 g of Composition A / day, provided as four 375mg capsules for two weeks. Ingest the capsules directly with water. The iron content in composition A is about 57 mg iron / gram of composition A, resulting in an initial intake level of 85.5 mg iron per day, which is an iron salt such as ferrous sulfate (per day 165-195mg) of approximately 50% of the daily recommended standard of care.

[0229] Table 1: Study Demograp...

Embodiment 2

[0279] Figure 28 The experimental protocol is exemplified in . Subjects were pre-screened and only non-anemic patients (hemoglobin >8 g / dL) were selected to participate in the study. All subjects were instructed to stop taking iron supplements and / or iron-containing multivitamins, if available, four weeks prior to study initiation.

[0280] Six non-pregnant, non-postpartum female subjects suffering from iron deficiency were instructed to take 3.0 g / day of Composition B, provided in eight 375 mg capsules, for twelve weeks. The composition A content is about 74 mg iron / gram, and the intake level is 222 mg iron per day, which is the daily recommendation for iron salts such as ferrous sulfate (165-195 mg per day) for subjects suffering from iron deficiency Approximately 114% of standard of care.

[0281] Tolerability of Composition B was monitored by direct questioning and recording of adverse events and by completing weekly gastrointestinal discomfort questionnaires.

[0282...

Embodiment 3

[0286]Using a standard preclinical animal model of iron deficiency, we demonstrate that ferritin-expressing, iron-supplemented yeast is superior to the standard regimen of administering ferrous sulfate to treat iron deficiency.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

Disclosed is a composition comprising a microbe expressing ferritin. The composition also comprises elemental iron in an amount of at least 3% by weight on a dry matter basis of the microbe expressingferritin and the elemental iron. Also disclosed are ingestibles, dietary supplements, and pharmaceutical compositions comprising the composition. Also disclosed are methods for treating a subject comprising administering the composition to the subject. Also disclosed are methods of altering the composition of the gut bacterial microbiome in a subject, the method comprising administering the composition to the subject.

Description

[0001] cross reference [0002] This application claims priority to U.S. Provisional Application No. 62 / 680,238, filed June 4, 2018, entitled "Composition and Method for Treatment of Iron Deficiency." technical field [0003] The present disclosure relates to the management of nutrient deficiency and subsequent symptoms or diseases, and the management and modulation of the gut microbiome. Background technique [0004] Iron deficiency is the most common and prevalent nutritional disorder worldwide, affecting as many as 2 billion people. Iron is one of the most important non-organic substances in life and plays a major role in oxygen transport, short-term oxygen storage and energy production, which are some of its fundamental roles in biological physiology. Deficiency in iron absorption or excess iron loss results in suboptimal blood and / or tissue iron levels with a variety of symptoms. [0005] Current iron replacement options are clearly insufficient, and new strategies ar...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/26C12N1/19A61P25/28
CPCA61P25/28A61K33/26A23L33/14A23L33/16A23L33/165A23V2002/00A23L33/30A61K35/66A61K35/74A61K38/1709A61K45/06A61P7/06A23V2200/3204A23V2250/1592A23V2250/762A61K2300/00A23L33/17A61K36/06
Inventor D·沃尔夫詹姆斯·科纳
Owner SIDERO BIOSCI LLC
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap