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Compound calcium gluconate oral solution and preparation method thereof

A technology of calcium gluconate and oral solution, applied in the field of medicine, can solve problems such as injury, influence on consumer use, bad taste, etc., and achieve the effects of improving product safety, improving product stability, and improving product taste.

Pending Publication Date: 2021-03-26
HARBIN PHARM GROUP SANJING PHARMACEUTICAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the compound calcium gluconate oral solution on the market contains more auxiliary materials: such as preservatives: potassium sorbate, sodium benzoate; sweeteners: sucralose, cyclamate, disodium glycyrrhizinate, these auxiliary materials may cause harm to the human Injury, bad taste, affecting consumers' use

Method used

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  • Compound calcium gluconate oral solution and preparation method thereof
  • Compound calcium gluconate oral solution and preparation method thereof
  • Compound calcium gluconate oral solution and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] (1) Weigh a certain amount of purified water, place it in the deionization equipment, heat and boil the purified water to 100°C after deionization, separate 100ml of boiled deionized water and keep it warm for later use;

[0024] (2) Take 63% deionized water of the dispensing amount and add it to the liquid preparation tank, weigh 50.00 g of calcium gluconate, 50.00 g of calcium lactate and 4.1 ml of lactic acid, add it under constant stirring, continue to boil for 40 minutes, stop heating, Cool to 52°C and keep warm for later use;

[0025] (3) Take the boiled deionized water separated in step 1, add 102g of sucrose and 40g of glucose, after boiling and dissolving under stirring, add 10g of activated carbon, let it stand for 30 minutes, carry out plate frame plus microporous membrane filtration, add to In the liquid mixing tank of step 2, stir evenly.

[0026] (4) Add 0.12ml of essence, stir evenly, add deionized water cooled to 51°C after boiling, and dilute the medic...

Embodiment 2

[0029] (1) Weigh a certain amount of purified water, place it in the deionization equipment, heat and boil the purified water to 100°C after deionization, separate 150ml of boiled deionized water and keep it warm for later use;

[0030] (2) Take 68% deionized water of the dosage and add it to the liquid preparation tank, weigh 50.00 g of calcium gluconate, 50.00 g of calcium lactate and 4.3 ml of lactic acid, add it under constant stirring, continue to boil for 50 minutes, stop heating, Cool to 53°C and keep warm for later use;

[0031] (3) Take the boiled deionized water separated in step 1, add 110g of sucrose and 35g of glucose, after boiling and dissolving under stirring, add 10g of activated carbon, let it stand for 45 minutes, filter with a plate frame and a microporous membrane, add to In the liquid mixing tank of step 2, stir evenly.

[0032] (4) Add 0.14ml of essence, stir evenly, add deionized water cooled to 52°C after boiling, and dilute the medicinal solution to ...

Embodiment 3

[0035] (1) Weigh a certain amount of purified water, place it in the deionization equipment, heat and boil the purified water to 100°C after deionization, separate 150ml of boiled deionized water and keep it warm for later use;

[0036] (2) Get 65% deionized water of the dispensing amount and add it to the liquid preparation tank, weigh 50.00 g of calcium gluconate, 50.00 g of calcium lactate and 4.4 ml of lactic acid, add it under constant stirring, continue to boil for 55 minutes, stop heating, Cool to 54°C and keep warm for later use;

[0037] (3) Take the boiled deionized water separated in step 1, add 120g of sucrose, 41g of glucose, after boiling and dissolving under stirring, add 20g of activated carbon, let stand for 45 minutes, carry out plate frame plus microporous membrane filtration, add to In the liquid mixing tank of step 2, stir evenly.

[0038] (4) Add 0.16ml of essence, stir evenly, add deionized water cooled to 53°C after boiling, and dilute the medicinal so...

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Abstract

The invention provides a compound calcium gluconate oral solution and a preparation method thereof. The compound calcium gluconate oral solution comprises the following components: 45-55 parts of calcium gluconate, 40-55 parts of calcium lactate, 100-300 parts of cane sugar, 40-70 parts of glucose, 4-7 parts of lactic acid, 1-3 parts of essence and 950-1050 parts of purified water. The compound calcium gluconate oral solution is prepared from the raw materials and auxiliary materials through processing steps of dissolving, preparing, filtering, filling, circulating steam sterilization, packaging and the like. Compared with a traditional formula, the compound calcium gluconate oral solution is free of preservatives, good in taste and easily accepted by people, only cane sugar and glucose are added, the original flavor and taste of the product are kept, safety is improved, and antibacterial efficacy tests prove that the product has antibacterial efficacy; and activated carbon is added todecolorize cane sugar and glucose, so that the color of the solution meets the standard specification after an acceleration test under high sugar concentration, and the safety and stability of the finished product are effectively improved.

Description

technical field [0001] The invention relates to the technical field of medicines, in particular to a formula of compound calcium gluconate oral solution and a preparation method thereof. Background technique [0002] Compound Calcium Gluconate Oral Solution is a medicine made of high bioavailability and safe calcium gluconate and calcium lactate as raw materials, purified water, sucrose, glucose, lactic acid and essence as auxiliary materials, and is used for the prevention and treatment of calcium deficiency. This product is in the form of oral solution, without the disintegration and release process of tablets, and can be quickly absorbed and utilized by the human body. The saturation solubility of calcium gluconate is 3%, and it is easy to precipitate and precipitate. In order to improve product stability, we add calcium lactate to the prescription and optimize the sterilization time to improve product safety and stability. [0003] At present, the compound calcium gluco...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K31/19A61K31/191A61K47/26A61P3/14
CPCA61K9/0095A61K31/19A61K31/191A61K47/26A61P3/14A61K2300/00
Inventor 芦传有赵冬艳范宁周珩吕艳春王新国王群孙慧君张巍毕春艳曹瀚明邱伯臣
Owner HARBIN PHARM GROUP SANJING PHARMACEUTICAL CO LTD
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