Zinc gluconate oral solution and preparation method thereof

A zinc gluconate and oral solution technology, which is applied in the field of medicine, can solve problems such as bad taste, human injury, and influence on consumer use, and achieve the effects of improving product taste, increasing osmotic pressure, and improving product safety

Pending Publication Date: 2021-12-24
HARBIN PHARM GROUP SANJING PHARMACEUTICAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, zinc gluconate oral solutions on the market are all added with bacteriostatic agents (preservatives): potassium sorbate, benzoic acid, sodium benzoate, etc. These auxiliary materials will cause harm to the human body, and the taste is not good, which affects the use of consumers

Method used

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  • Zinc gluconate oral solution and preparation method thereof
  • Zinc gluconate oral solution and preparation method thereof
  • Zinc gluconate oral solution and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] (1) Take 3000ml of purified water, heat to boil, add 30g of zinc gluconate under stirring, dissolve and heat to boiling;

[0019] (2) Weigh 1500g of sucrose, slowly add in (1) boiling solution, stir evenly, boil for 20min, stop heating, cool down, set aside;

[0020] (3) Weigh 3 g of citric acid, add purified water to prepare a 30% citric acid solution, and sterilize it at 105° C. for 30 minutes in an airtight manner before use.

[0021] (4) Add (3) to the solution in (2), add an appropriate amount of purified water, adjust the pH value to 3.0-5.0, add purified water to 10000ml, stir well, and fine filter through a 5 μm titanium rod and a 1 μm folded membrane;

[0022] (5) Filling after filtration, airtight sterilization at 100-110°C for 50 minutes.

Embodiment 2

[0024] (1) Take 3500ml of purified water, heat to boil, add 35g of zinc gluconate under stirring, dissolve and heat to boiling;

[0025] (2) Weigh 2000g of sucrose, slowly add in (1) boiling solution, stir evenly, boil for 60min, stop heating, cool down, and set aside;

[0026] (3) Weigh 2.5 g of citric acid, add purified water to prepare a 30% citric acid solution, and sterilize it at 105° C. for 30 minutes in an airtight manner before use.

[0027] (4) Add (3) to the solution in (2), add an appropriate amount of purified water, adjust the pH value to 3.0-5.0, add purified water to 10000ml, stir well, and fine filter through a 5 μm titanium rod and a 1 μm folded membrane;

[0028] (5) Filling after filtration, airtight sterilization at 100-110°C for 60 minutes.

Embodiment 3

[0030] (1) Take 4000ml of purified water, heat to boil, add 40g of zinc gluconate under stirring, dissolve and heat to boiling;

[0031] (2) Weigh 3000g of sucrose, slowly add it into (1) boiling solution, stir evenly, boil for 40min, stop heating, cool down, and set aside;

[0032] (3) Weigh 2.5 g of citric acid, add purified water to prepare a 30% citric acid solution, and sterilize it at 105° C. for 30 minutes in an airtight manner before use.

[0033] (4) Add (3) to the solution in (2), add an appropriate amount of purified water, adjust the pH value to 3.0-5.0, add purified water to 10000ml, stir well, and fine filter through a 5 μm titanium rod and a 1 μm folded membrane;

[0034] (5) Filling after filtration, airtight sterilization at 100-110°C for 50 minutes.

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PUM

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Abstract

The invention provides a compound calcium gluconate oral solution and a preparation method thereof. The compound calcium gluconate oral solution comprises 0.3%-0.5% of zinc gluconate, 15%-50% of cane sugar and 0.02%-0.03% of citric acid. The preparation method comprises the following processes: dissolving the raw and auxiliary materials, performing boiling for 20-60 minutes, adjusting the pH value to 3-5, performing filtering, performing sealing and sterilizing at the temperature of 100-110 DEG C for 20-60 minutes, and the like. A hypertonic solution is formed through raw material proportioning and preparation process conditions, antibacterial efficacy tests prove that the product has antibacterial efficacy. Compared with a traditional formula, the product is free of preservatives, good in taste and easy to accept by people, so that the safety and stability of a finished product are effectively improved.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a formulation of zinc gluconate oral solution and a preparation method thereof. Background technique [0002] Bacteriostatic agents refer to chemical substances that inhibit the growth of microorganisms, sometimes also called preservatives. All bacteriostatic agents have certain toxicity, and the amount of bacteriostatic agent in the preparation should be the minimum effective amount. Zinc gluconate oral solution on the market all adds bacteriostat (preservative): potassium sorbate, benzoic acid, sodium benzoate etc., these auxiliary materials can cause harm to human body, and mouthfeel is bad, affects consumer to use. Therefore, how to improve the stability of the product while improving the compliance and safety of the product is a problem that those skilled in the art have always wanted to solve. [0003] Inquired on the website of the State Intellectual Property Office, th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K31/315A61K47/12A61K47/26
CPCA61K31/315A61K9/0095A61K47/26A61K47/12
Inventor 谢英新赵冬艳范宁周珩解爱莉王新国杨利红刘利群齐鹤姚慧敏王博妍褚利娟赵海英金焱杜进栾东晓曹翰明张彩霞郑巧云齐欣李涛王征林邹月春胡帅赵志鹏王敬伟
Owner HARBIN PHARM GROUP SANJING PHARMACEUTICAL CO LTD
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