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Application of trifluoroicaritin in preparation of medicine for improving pain, swelling and movement functions

A technology of motor function and epimedium trifluoride, which is applied in the field of medicine, can solve the problems of no treatment plan, complicated pathogenesis of chronic inflammatory pain, and large side effects

Pending Publication Date: 2021-03-30
GANNAN MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the complex pathogenesis of chronic inflammatory pain, variable clinical manifestations, large individual differences, long course of disease and other factors, combined medication is often used in clinical practice with long treatment course and side effects, and the best treatment plan has not yet been found.

Method used

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  • Application of trifluoroicaritin in preparation of medicine for improving pain, swelling and movement functions
  • Application of trifluoroicaritin in preparation of medicine for improving pain, swelling and movement functions
  • Application of trifluoroicaritin in preparation of medicine for improving pain, swelling and movement functions

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Experimental program
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Effect test

Embodiment 1

[0021] 1. Experimental group:

[0022] Method 1, 60 SD rats (150-170g) were randomly divided into 6 groups, 10 in each group, the first group (Ctrl group, subcutaneous injection of 100 μl normal saline in the left hind foot without drug treatment); the second group (CFA group, subcutaneous injection of 100 μl CFA in left hind foot without drug treatment); the third group (CFA+DMSO group, subcutaneous injection of 100 μl CFA in left hind foot + intraperitoneal injection of DMSO, wherein the volume of DMSO intraperitoneal injection was 0.05 per 100 g of body weight ml DMSO); the fourth group (CFA+0.3mg / kg ICTF group, subcutaneous injection of 100μl CFA+intraperitoneal injection of 0.3mg / kg body weight ICTF in the left hind foot, ICTF was prepared with DMSO, the concentration was 0.6mg / ml, and the volume of intraperitoneal injection was Inject 0.6mg / ml ICTF per 100g body weight (0.05ml); the fifth group (CFA+1mg / kg ICTF group, subcutaneously inject 100μl CFA + intraperitoneally i...

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Abstract

The invention discloses an application of trifluoroicaritin in preparation of a medicine for improving pain, swelling and movement functions. The application of the trifluoroicaritin in the medicine for treating the chronic inflammatory pain proves that the trifluoroicaritin can effectively relieve mechanical pain sensitivity and heat pain sensitivity of the chronic inflammatory pain, improve thetissue swelling degree and the movement function of the chronic inflammatory pain, up-regulate the protein and mRNA level of alpha7nAChR and IL-10 and down-regulate the protein and mRNA level of HMGB1, p-NF-kappaB (p-P65) and IL-1beta. Therefore, the trifluoroicaritin is a medicine which has development potential and is used for treating chronic inflammatory pain.

Description

Technical field: [0001] The invention belongs to the field of medicine, and specifically relates to the application of trifluoroicariin in the preparation of drugs for activating α7nAChR and inhibiting HMGB1-NF-κB and the application of trifluoroicariin in the preparation of drugs for improving pain, swelling and motor function. Background technique: [0002] Chronic inflammatory pain is one of the diseases that seriously threaten human health. It is common and persists in the course of many diseases, and it still plagues countless patients. Clinically, chronic inflammatory pain is induced by trauma, infection, chemical stimulation or surgical operation. Its main clinical manifestations are redness, swelling, heat, pain and dysfunction. Inflammation is the body's response to injury and infection, involving complex biological regulation of somatosensory, immune, autonomic, and vascular systems. Inflammatory mediators such as prostaglandins, pro-inflammatory cytokines, and ch...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/352A61P29/00
CPCA61K31/352A61P29/00
Inventor 黄诚孙亚兰贾丹丹胡志苹夏阳阳黄志华
Owner GANNAN MEDICAL UNIV
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