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A matrix-assisted laser desorption ion source device

A matrix-assisted laser and ion source technology, applied in the direction of ion source/gun, measuring device, particle separation tube, etc., can solve the problems of complex mechanical structure and control mode, higher requirements for electromechanical control parts, high cost of motion control mechanism, etc. , to achieve the effect of simple and reliable structure

Active Publication Date: 2021-09-17
FUDAN UNIV
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  • Description
  • Claims
  • Application Information

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Problems solved by technology

In order to automate the process of isolating the high and low vacuum chambers and replacing the target plate, the corresponding mechanical design of this part of the existing foreign instruments can complete this process, but the mechanical structure and control methods are relatively complicated; in addition, due to the movement The control mechanism operates in a vacuum, which has higher requirements on the components of the electromechanical control part, resulting in higher cost of the motion control mechanism

Method used

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  • A matrix-assisted laser desorption ion source device
  • A matrix-assisted laser desorption ion source device
  • A matrix-assisted laser desorption ion source device

Examples

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Embodiment Construction

[0024] The ion introduction device 7 and the ion source sealing cover 10 are fixed with screws, and the contact surface is vacuum-tight through an O-ring. The ion source sealing cover plate 10 and the ion source cavity 11 are fixed with screws, and the contact surface is vacuum-tight through an O-ring. One end of the target plate hatch 9 is connected and fixed on the ion source sealing cover 10 by a hinge, and the other end is adsorbed on the ion source sealing cover 10 by a magnet, and the target plate hatch 9 can be opened from one side to replace the target plate 6 . The two-dimensional motion mechanism 1 is fixed on the bottom of the ion source cavity 11 by screws. The insulating plate 4 and the target plate mounting seat 5 are fixed on the two-dimensional mobile platform by screws. Since the target plate mounting base 5 needs to be applied with high-voltage pulses, the electrical insulation between the target plate mounting base 5 and the platform of the two-dimensional ...

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Abstract

The invention belongs to the technical field of laser desorption ionization, and in particular relates to a matrix-assisted laser desorption ion source device. Device of the present invention. The device of the present invention consists of a two-dimensional motion mechanism, a gasket, a gasket mounting seat, an insulating plate, a target plate mounting seat, a target plate, an ion channel sealing seat, a target plate hatch, an ion introduction device, an ion source sealing cover plate, and an ion source. The cavity is composed of a mating connection. Through the simple and ingenious mechanical design and target plate moving strategy, the device can conveniently and quickly complete the target plate replacement of the matrix-assisted laser desorption ion source, and the structure is simple and reliable; when replacing the target plate, no complicated mechanical device is required to achieve vacuum sealing.

Description

technical field [0001] The invention belongs to the technical field of laser desorption ionization, and in particular relates to a matrix-assisted laser desorption ion source device. Background technique [0002] Matrix-assisted laser desorption ionization (MALDI) is a soft ionization method that uses laser light of a specific wavelength (usually 337nm or 355nm) to irradiate the target plate, and the matrix on the target plate transfers the absorbed energy to the sample, making the sample An instantaneous expansion phase transition occurs and bulk desorption occurs to ionize the sample. Since the ionization process needs to be carried out under low vacuum, when the sample needs to be replaced, it is necessary to isolate the low vacuum chamber where the target motion system is located from the high vacuum chamber where the ions are introduced, and then the low vacuum chamber chamber to deflate. When the air pressure of the low vacuum chamber reaches the atmospheric pressure...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): H01J49/16H01J49/24G01N27/64
CPCG01N27/64H01J49/164H01J49/24
Inventor 朱晨鑫熊悦婷杨爽刘凯杨芃原
Owner FUDAN UNIV