High-mechanical-property tetracalcium phosphate nano-powder for 3D printing and preparation method thereof

Abstract

The invention discloses a preparation method of tetracalcium phosphate nano-powder with high mechanical properties for 3D printing. The preparation method comprises the following steps: (1) mixing a lithium salt, a calcium salt, sodium chloride and water; (2) mixing a rare earth compound, water glass and water, and dropwise adding the mixture into the mixture in the step (1); (3) mixing a titanium source and water, and dropwise adding the mixture into the mixture obtained in the step (2); (4) heating the reactant prepared in the step (3) in a closed manner, carrying out a heat preservation reaction, conducting cooling, discharging, filtering and washing to obtain a filter cake, and roasting the filter cake to obtain electronegative phyllosilicate; (5) mixing the electronegative phyllosilicate prepared in the step (4) with water, then adding calcium chloride, disodium hydrogen phosphate, sodium hydroxide and calcium carbonate, uniformly conducting mixing, conducting heating under a closed condition, and then carrying out heat preservation and stirring reaction; and (6) filtering the reaction solution obtained in the step (5), conducting washing to obtain a filter cake, roasting the filter cake, conducting cooling, and conducting grinding until the particle size is not more than 200 meshes. The tetracalcium phosphate nano-powder has excellent mechanical properties.

Description

technical field [0001] The invention belongs to the technical field of 3D printing materials, in particular to a tetracalcium phosphate nano-powder with high mechanical properties for 3D printing and a preparation method thereof. Background technique [0002] Human beings have been suffering from orthopedic diseases for a long time. Every year, a large number of patients suffer from orthopedic diseases and need surgical treatment such as bone defect repair and reconstruction. Therefore, bone repair biomaterials are widely used in clinical medicine, involving many fields of clinical medicine, such as orthopedic surgery, stomatology, and craniocerebral surgery. For a long time, people have gradually developed biomedical metal materials, polymer biorepair materials, etc., but these bone repair materials are not easy to shape, difficult to match the shape of bone defects, and have poor biocompatibility, large human immune rejection, and They cannot be degraded in the human body...

AI Technical Summary

Problems solved by technology

[0005] (1) Mechanical properties are a prerequisite for the practical use of all bone repair materials, but the mechanical properties of the finished bone repair materials produced by the existing TTCP through 3D printers are poor (for example, the compressive strength is less than 10 MPa, and the bending strength is not higher than 1 MPa. ), not only far from meeting the requirements of compact bone, but even basically completely unable to meet the requirements of cancellous bone

This is the biggest key technical bottleneck of TTCP / 3D printing technology, which seriously restricts its further technical development and medical application.

[0006] (2) High-purity TTCP cannot be prepared through the existing technology, which also seriously restricts the application of TTCP / 3D printing technology in clinical medicine

Regardless of the dry process (high-temperature solid-phase method) or wet process, even if it is roasted at a high temperature of up to 1400 ° C for at least 5 hours, a series of intermediate products that hinder the formation of TTCP will still be formed during the roasting stage, resulting in many products such as triphosphate Calcium, hydroxyapatite and other by-products make the purity of TTCP very low

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