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Compositions and methods for treatment of exocrine pancreatic insufficiency (EPI)

An insufficiency and exocrine technology, applied in drug combination, endocrine system diseases, drug delivery, etc., can solve problems such as interference with proteolytic enzyme and amylolytic enzyme activity, lipolysis activity, etc., and achieve the effect of improving the quality of life

Pending Publication Date: 2021-04-09
NESTEC SA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Finally, diets rich in fiber content may be contraindicated in some CF patients because fibrous materials will interfere with proteolytic and amylolytic enzyme activities; lipolytic activity is most affected

Method used

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  • Compositions and methods for treatment of exocrine pancreatic insufficiency (EPI)
  • Compositions and methods for treatment of exocrine pancreatic insufficiency (EPI)
  • Compositions and methods for treatment of exocrine pancreatic insufficiency (EPI)

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Experimental program
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Embodiment approach

[0074] The present disclosure provides nutritional compositions wherein at least a portion of the macronutrients are in predigested form and / or in a form that does not require the use of pancreatic enzymes for digestion. Preferably, the composition has total protein consisting essentially of hydrolyzed protein and total fat comprising at least about 30% by weight monoacylglycerol (MAG) of the total fat, and optionally the total fat further comprising Medium Chain Triglycerides (MCT) and / or Fatty Acids. Optionally, at least a portion of the hydrolyzed protein may be substantially hydrolyzed protein.

[0075] In one embodiment, MAG can provide all of the fatty acids present in an edible oil (eg, soybean oil) in order to deliver effective amounts of essential fatty acids. Furthermore, in this regard, the fat source of the compositions disclosed herein is formulated to provide the patient with the necessary lipids, including all essential fatty acids, and to provide the lipids in...

Embodiment 1

[0126] Element

Embodiment 2

[0128]

[0129]

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Abstract

A method of treating exocrine pancreatic insufficiency includes administering to an individual in need thereof (e.g., an individual with cystic fibrosis) an effective amount of an enteral composition having a total protein consisting essentially of hydrolyzed protein and a total fat containing monoacylglycerols (MAG) that are at least about 30 wt.% of the total fat, and the total fat optionally further contains medium chain triglycerides (MCT) and / or fatty acids. In one particular non- limiting embodiment, about 60 wt.% of the total fat is from MCT and about 40 wt.% of the total fat is from MAG; in another particular non- limiting embodiment, the total fat is MAG with free fatty acids (esterified and / or bound) without MCT; and in yet another particular non- limiting embodiment, the total fat is MAG alone without MCT.

Description

Background technique [0001] The present disclosure relates generally to nutritional compositions and methods that can treat exocrine pancreatic insufficiency, for example, in individuals with cystic fibrosis. The composition is advantageously stable. [0002] A properly functioning pancreas ensures efficient digestion of nutrients. Exocrine pancreatic insufficiency (EPI) occurs when the secretion of pancreatic enzymes fails to maintain normal digestive function, resulting in malabsorption of food (diarrhea) and ultimately malnutrition. In children, growth and development may be impaired by EPI. [0003] Indeed, patients with EPI have reduced secretion of digestive enzymes. As a result, patients with EPI have limited ability to digest, absorb, and utilize nutrients from food. Without appropriate treatment, patients with EPI are at high risk of malnutrition and experience low quality of life. [0004] The most common causes of primary EPI are cystic fibrosis (CF) and pancre...

Claims

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Application Information

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IPC IPC(8): A23L33/00A61K31/00A61P1/12A61P1/18A61P5/48
CPCA23L33/40A61P1/12A61P1/18A61P5/48A61K45/06A61K31/23A61K9/0029A61K9/0056A61K47/26A61K47/36A61K2300/00A23L33/12A23L33/17A23L33/125
Inventor R·兰-雷斯勒D·S·菲利普J·雅各布
Owner NESTEC SA