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Pharmaceutical composition taking metformin or pharmaceutical salts thereof and omarigliptin or pharmaceutical salts thereof as active ingredients

A technology of metformin and metformin hydrochloride, which is applied in the directions of organic active ingredients, medical preparations containing active ingredients, drug combinations, etc., can solve problems such as research reports on the combination of antidiabetic drugs without ausagliptin

Inactive Publication Date: 2021-04-13
JIANGSU JINGLIXIN PHARMA TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0013] In the prior art, there is no research report on the combination of alogliptin and other hypoglycemic drugs

Method used

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  • Pharmaceutical composition taking metformin or pharmaceutical salts thereof and omarigliptin or pharmaceutical salts thereof as active ingredients
  • Pharmaceutical composition taking metformin or pharmaceutical salts thereof and omarigliptin or pharmaceutical salts thereof as active ingredients
  • Pharmaceutical composition taking metformin or pharmaceutical salts thereof and omarigliptin or pharmaceutical salts thereof as active ingredients

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Example 1 Metformin Hydrochloride and Alogliptin Hydrochloride Tablets

[0023]

[0024] Preparation:

[0025] Pass metformin hydrochloride and alogliptin hydrochloride through a 60-mesh sieve respectively, then mix metformin hydrochloride, hydroxypropyl cellulose and alogliptin hydrochloride evenly, granulate and dry in a fluidized bed, pass through a 30-mesh sieve for granulation, and add Magnesium stearate is mixed evenly, and a suitable die is selected to compress the tablet to obtain final product.

[0026] A suitable coating material is selected for the above-mentioned compressed tablet to obtain a coated tablet, which can be a film-coated tablet, an enteric-coated tablet, or the like.

Embodiment 2

[0027] Example 2 Metformin Hydrochloride and Alogliptin Hydrochloride Capsules

[0028]

[0029] Preparation:

[0030] Pass metformin hydrochloride and alogliptin hydrochloride through a 60-mesh sieve respectively, then mix metformin hydrochloride, hydroxypropyl cellulose and alogliptin hydrochloride evenly, granulate and dry in a fluidized bed, pass through a 30-mesh sieve for granulation, and add The magnesium stearate is evenly mixed, filled, and obtained.

[0031] The capsule shell used for filling is an ordinary capsule shell.

Embodiment 3

[0032] Embodiment 3 Metformin Hydrochloride and Alogliptin Hydrochloride Dispersible Tablets

[0033]

[0034] Preparation:

[0035] Metformin hydrochloride, alogliptin hydrochloride, and microcrystalline cellulose were passed through 80-mesh sieves, mixed evenly, and 75% ethanol solution was added to prepare soft materials, granulated through 20-mesh sieves, dried, and granulated through 20-mesh sieves. Add the remaining auxiliary materials and mix evenly, select a suitable die to compress the tablet, and it is ready.

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Abstract

The invention discloses a pharmaceutical composition taking metformin or pharmaceutical salts thereof and omarigliptin or pharmaceutical salts thereof as active ingredients. Pharmacological research results show that the pharmaceutical composition of metformin hydrochloride and omarigliptin hydrochloride can improve the pancreatic islet form of a test animal, effectively reduce the blood glucose level of a diabetic model animal and improve glucose tolerance; the hypoglycemic effect is dose-dependent; and furthermore, the hypoglycemic effect is rapid, stable and lasting.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, in particular to a pharmaceutical composition containing metformin or a pharmaceutically acceptable salt thereof and alogliptin or a pharmaceutically acceptable salt thereof. Background technique [0002] Diabetes is a group of metabolic diseases characterized by hyperglycemia. Hyperglycemia is caused by defective insulin secretion or impaired biological action, or both. The chronic hyperglycemic state of diabetes is significantly associated with long-term complications, namely damage, dysfunction, and failure of numerous organs, especially the kidneys, eyes, nerves, heart, and blood vessels. The comprehensive treatment of diabetes should not only focus on reducing blood sugar to near normal levels, but also actively correct metabolic abnormalities and reduce cardiovascular risk factors. [0003] The current definition of diabetes is based on WHO / ADA criteria, that is, sympt...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/407A61K31/155A61P3/10
CPCA61K31/407A61K31/155A61P3/10
Inventor 操锋高盛凯朱雄
Owner JIANGSU JINGLIXIN PHARMA TECH CO LTD
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