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Anti-tumor pharmaceutical composition, preparation and application thereof

A technology of anti-tumor drugs and compositions, which is applied in the field of medicine and can solve problems such as patent publications that have not yet been found

Pending Publication Date: 2021-04-30
TIANJIN UNIVERSITY OF SCIENCE AND TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Through the search, no patent publications related to the patent application of the present invention have been found

Method used

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  • Anti-tumor pharmaceutical composition, preparation and application thereof
  • Anti-tumor pharmaceutical composition, preparation and application thereof
  • Anti-tumor pharmaceutical composition, preparation and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] To study the inhibitory effects of single drugs Topotecan, Crizotinib and Metformin on the proliferation of H1975 and HCC827 cells, this

[0053] IC of three single drugs in three cells 50 The values ​​are shown in Table 1.

[0054] Table 1 IC of single drug Topotecan, Crizotinib and Metformin on lung cancer cells 50 value

[0055]

Embodiment 2

[0057] The experimental results of the inhibitory effect of different concentrations of single drug Metformin, TC and Topotecan, Crizotinib and Metformin on the proliferation of H1975 cells are shown in figure 1 , the CI value of the composition see figure 2 . from figure 1 and figure 2 It can be seen that the CI<1 of the composition indicates that compared with Metformin single drug and TC, Topotecan, Crizotinib and Metformin composition have good superiority.

Embodiment 3

[0059] The experimental results of the inhibitory effect of single drug Metformin, TC and Topotecan, Crizotinib and Metformin composition on HCC827 cell proliferation at different concentrations are shown in figure 1 , the CI value of the composition see figure 2 . from figure 1 and figure 2 It can be seen that the CI<1 of the composition indicates that compared with Metformin single drug and TC, Topotecan, Crizotinib and Metformin composition have good superiority.

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Abstract

The invention relates to an anti-tumor pharmaceutical composition, which is a composition of Topotecan, Crizotinib and Metformin, Topotecan, Crizotinib and Metformin are combined for use, the composition has a good treatment effect on non-small cell lung cancer under the condition of low dosage, and in vitro experiments find that the composition has a better treatment effect on non-small cell lung cancer compared with Topotecan and Metformin. A new thought is provided for treatment of non-small cell lung cancer with drug resistance, hope is brought to patients with diabetes mellitus and non-small cell lung cancer, a scientific basis is provided for research and development of new drugs, and the application prospect is wide.

Description

technical field [0001] The invention belongs to the technical field of medicine, in particular to a class of antitumor drug composition, preparation and application. Background technique [0002] The mortality rate of lung cancer accounts for the first place in the mortality rate of tumors. Lung cancer is morphologically divided into non-small cell lung cancer and small cell lung cancer. The incidence of non-small cell lung cancer accounts for 85% of the total incidence of lung cancer. The 5-year survival rate of lung cancer is only 15%. Therefore, effective treatment of non-small cell lung cancer can significantly reduce the mortality rate of lung cancer. Chemotherapy and targeted therapy are the two major methods for the treatment of non-small cell lung cancer at present, but the toxicity of chemotherapy drugs is relatively high. It is large and often causes great side effects, which has become a major obstacle to its clinical use. Although targeted drugs can target tumor ...

Claims

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Application Information

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IPC IPC(8): A61K31/4375A61K31/4545A61K31/155A61P35/00A61P3/10
CPCA61K31/4375A61K31/4545A61K31/155A61P35/00A61P3/10A61K2300/00
Inventor 刘振邱亚楠徐烨
Owner TIANJIN UNIVERSITY OF SCIENCE AND TECHNOLOGY
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