Active micro-fluidic chip

A chip, active technology, applied in the direction of material inspection products, measuring devices, instruments, etc., can solve the problems of increasing the difficulty of forming the chip body, the difficulty of assembly, and the high production cost, and achieve the effect of facilitating assembly, reducing resistance, and improving blood filtration efficiency.

Pending Publication Date: 2021-05-25
NANJING LANSION BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the sample injection cavity mentioned in the above-mentioned patents, the sample filter components arranged therein, such as the blood filter membrane, are all sealed in the chip body, which increases the difficulty of forming and assembling the chip body on the one hand, and on the other hand higher production costs

Method used

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  • Active micro-fluidic chip
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  • Active micro-fluidic chip

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0088] like Figures 1 to 7 As shown, the active microfluidic chip according to the present invention includes a chip body, the chip body is provided with a sample injection cavity, and the sample injection cavity is provided with a blood filtration module placement part, and the blood filtration module placement part is equipped with There is a blood filtration module; the blood filtration module includes a sample injection connection joint and a blood filtration assembly, and the sample injection connection joint is divided into a first clamping part 44 and a second clamping part 43 .

[0089] The first clip 44, such as figure 1 As shown, it is an annular member with a through hole in the middle, and a support structure is provided along the circumference of the inner wall of the through hole; the support structure is an annular boss provided along the circumference of the inner hole of the first clamping member 44 . In this embodiment, the first clip 44 is a cylindrical m...

Embodiment 2

[0112] like Figure 8 to Figure 11 As shown, most of the structures of this embodiment are the same as that of Embodiment 1, and the only difference is:

[0113]1. In this embodiment, the first clamping member 44 is directly supported by the blood filtration module placement part, and is clamped with the blood filtration module placement part when the connecting lug is engaged with the chip body. Specifically, in this embodiment, the through hole provided at the lower end of the first clamping member 44 abuts against the blood filtration module installation hole a provided on the middle chip 2, and the lower end of the first clamping member 44 extends outward. An annular flange is provided, and the annular flange is supported by the middle chip 2 outside the installation hole a of the blood filtration module, and the upper end of the first clip 44 is set through the installation hole b of the blood filtration module. In addition, in this embodiment, the clamping hole is provi...

Embodiment 3

[0118] like Figure 12-18 As shown, the active microfluidic chip disclosed in this embodiment is the same as most of the structures of the active microfluidic chip disclosed in Example 1, and the only difference is:

[0119] 1. In this embodiment, the cross-section of the sampling pool 1-1 arranged on the front of the lower chip is circular, and a collection flow channel 1-1-1 is set from the middle of the circular sampling pool to directly communicate with To the sample outlet of the sample pool 1-1, so as to communicate with the sample outlet channel of the sample pool 1-1-1.

[0120] 2. In this embodiment, the diluent inlet 3-3 and the external gas outlet 3-8 set on the upper chip are all set as embedded structures, that is, the diluent inlet 3-3 and the external gas outlet 3- 8 are all set as embedded interfaces at the interface positions, and fluid through holes are provided on the bottom surface of the embedded interfaces to communicate with the corresponding internal f...

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PUM

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Abstract

The invention discloses a micro-fluidic chip. The chip comprises a chip body provided with a sample introduction cavity, and is characterized in that the sample introduction cavity is provided with a blood filtering module placement part, and the blood filtering module placement part is provided with a blood filtering module; the blood filtering module comprises a sample introduction connector and a blood filtering assembly; and the blood filtering assembly is embedded in the sample introduction connector or is arranged between the sample introduction connector and the blood filtering module placement part. Therefore, the blood filtering module is independent from the chip body, so that the blood filtering efficiency can be improved, and the chip is convenient to assemble.

Description

technical field [0001] The invention relates to an active microfluidic chip. Background technique [0002] Immunolateral flow-through diagnostic technology is a stable and practical technology suitable for use in various point-of-care tests (POCT) or on-site. In the immunochromatographic reaction system, due to system reasons, the CV is large and accurate quantification cannot be achieved. The immunodiagnostic method based on microfluidic technology can effectively avoid the above problems. [0003] There are two types of microfluidics: passive and active. Among them: Passive microfluidics requires capillary force to achieve liquid-forward lateral flow. However, due to the different viscosities of different samples, especially whole blood samples, the liquid flow rate cannot be uniform. Active microfluidics can effectively avoid the above problems, and can give forward thrust to make the liquid flow forward evenly, avoiding the difference in test values ​​caused by diffe...

Claims

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Application Information

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IPC IPC(8): B01L3/00G01N33/53G01N33/558
CPCB01L3/5027B01L3/502715B01L3/502723B01L3/502753B01L2200/021B01L2200/028B01L2200/0684B01L2300/0681B01L2300/0809B01L2300/0861B01L2300/0887G01N33/5304G01N33/558
Inventor 许行尚杰弗瑞·陈
Owner NANJING LANSION BIOTECH CO LTD
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