Application of quassin type diterpenoid compound in preparation of medicine for treating cholestatic liver disease

A cholestasis and bitternin technology, applied in the field of medicine, can solve problems such as poor response to UDCA, intolerance to UDCA, and obvious side effects of OCA

Active Publication Date: 2021-05-28
TIANJIN UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, nearly 40% of PBC patients do not respond well to UDCA, 5% to 10% of patients are intolerant to UDCA, and the side effects of OCA are also very obvious
There is no literature report on the treatment of cholestatic liver disease with picrophyllin-type diterpenoids

Method used

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  • Application of quassin type diterpenoid compound in preparation of medicine for treating cholestatic liver disease
  • Application of quassin type diterpenoid compound in preparation of medicine for treating cholestatic liver disease
  • Application of quassin type diterpenoid compound in preparation of medicine for treating cholestatic liver disease

Examples

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preparation example Construction

[0068] As an example of extracting pectinoid diterpenoids from the root of Tongkat Ali, the preparation method comprises the following steps:

[0069] (i) extract Tongkat Ali root with an alcohol solution with a volume concentration of 50% to 90%, and concentrate the extract to obtain the extract;

[0070] (ii) extracting the extract obtained in step (i) to obtain an organic phase extract and an aqueous phase extract respectively;

[0071] (iii) The aqueous phase extract obtained in step (ii) is sequentially eluted with the following solvents on the macroporous adsorption resin column: (a) water or an alcoholic solution with a concentration lower than 40%, (b) 40 -75% alcohol solution, (c) 80-95% alcohol solution;

[0072] (iv) Concentrate the eluate obtained by eluting with (c) 80-95% alcohol solution in step (iii), and use it on a gel chromatography column in a volume ratio of 1:2 to 2:1 The alcohol / water solution was used for elution, and the eluate was collected, concent...

Embodiment

[0090] The content of the present invention is further explained or illustrated by examples below, but these examples should not be construed as limiting the protection scope of the present invention.

[0091] It should be noted that, in the following examples, except for the medicines and reagents whose sources are indicated, other various conventional reagents are known in the art and can be obtained commercially. In addition, each testing instrument used in the present invention is also a conventional instrument known in the art.

[0092] Drugs and Reagents

[0093] Eurycomanone (Eurycomanone, EN): purchased from MCE (MedChemExpress), product number: HY-N5012.

[0094] α-Naphthalene isothiocyanate (ANIT): purchased from Sigma-Aldrich, product number: N4525.

[0095] Ursodeoxycholic acid (UDCA): purchased from MCE (MedChemExpress), product number: HY-13771

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Abstract

The invention discloses a novel medical application of a quassin type diterpenoid compound represented by eurycomanone in treating cholestatic liver diseases. Tests show that the eurycomanone can obviously improve the cholestasis condition and obviously relieve the change degree of pathological injury of the liver caused by cholestasis, so that the effect of treating the cholestatic liver disease is achieved.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to the application of pectinoid diterpene compounds in the preparation of medicines for treating cholestatic liver disease. Background technique [0002] Cholestasis is a common pathological process in liver diseases, clinically manifested as skin itching and jaundice, and the main cause is obstruction of bile production or bile flow disturbance. Cholestasis can be divided into two types: acute and chronic according to the course of the disease. Acute cholestasis is generally caused by biliary obstruction, sepsis, intrahepatic cholestasis during pregnancy, alcoholic hepatitis, etc. Chronic cholestasis (duration of more than 6 months) is generally caused by biliary atresia , primary biliary cirrhosis (PBC), primary sclerosing cholangitis (PSC), drug-induced liver injury, etc. [0003] During cholestasis, serum γ-GT (γ-glutamyl transferase), ALP (alkaline phosphatase), AST (aspart...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/366A61K31/7048A61P1/16A61P31/12A61P31/00
CPCA61K31/366A61K31/7048A61P1/16A61P31/12A61P31/00
Inventor 刘梦扬王涛张祎袁若兰沈佳妍贾博娜王丹高秀梅
Owner TIANJIN UNIV OF TRADITIONAL CHINESE MEDICINE
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