Application of quassin type diterpenoid compound in preparation of medicine for treating cholestatic liver disease

A cholestasis and bitternin technology, applied in the field of medicine, can solve problems such as poor response to UDCA, intolerance to UDCA, and obvious side effects of OCA
CN112843050AActive Publication Date: 2021-05-28TIANJIN UNIV OF TRADITIONAL CHINESE MEDICINE
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
TIANJIN UNIV OF TRADITIONAL CHINESE MEDICINE
Publication Date
2021-05-28

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Abstract

The invention discloses a novel medical application of a quassin type diterpenoid compound represented by eurycomanone in treating cholestatic liver diseases. Tests show that the eurycomanone can obviously improve the cholestasis condition and obviously relieve the change degree of pathological injury of the liver caused by cholestasis, so that the effect of treating the cholestatic liver disease is achieved.
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Description

technical field

[0001] The invention belongs to the field of medicine, and in particular relates to the application of pectinoid diterpene compounds in the preparation of medicines for treating cholestatic liver disease. Background technique

[0002] Cholestasis is a common pathological process in liver diseases, clinically manifested as skin itching and jaundice, and the main cause is obstruction of bile production or bile flow disturbance. Cholestasis can be divided into two types: acute and chronic according to the course of the disease. Acute cholestasis is generally caused by biliary obstruction, sepsis, intrahepatic cholestasis during pregnancy, alcoholic hepatitis, etc. Chronic cholestasis (duration of more than 6 months) is generally caused by biliary atresia , primary biliary cirrhosis (PBC), primary sclerosing cholangitis (PSC), drug-induced liver injury, etc.

[0003] During cholestasis, serum γ-GT (γ-glutamyl transferase), ALP (alkaline phosphatase), AST (aspart...

Claims

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