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Biomarker capable of detecting polycystic ovarian syndrome and application thereof

A biomarker, polycystic ovary technology, applied in biostatistics, bioinformatics, microbial determination/inspection, etc.

Pending Publication Date: 2021-06-01
GUANGDONG HOSPITAL OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Although some medical staff or scholars have put forward some ideas or conducted some useful explorations, up to now, there is still no more accurate and efficient method that can quickly identify, diagnose and effectively treat polycystic ovary syndrome. purpose of sign

Method used

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  • Biomarker capable of detecting polycystic ovarian syndrome and application thereof
  • Biomarker capable of detecting polycystic ovarian syndrome and application thereof
  • Biomarker capable of detecting polycystic ovarian syndrome and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0021] 1 Materials and methods:

[0022] 1.1 Research object:

[0023] A total of 19 PCOS patients who visited the Gynecology Clinic of Guangdong Provincial Hospital of Traditional Chinese Medicine from June 2018 to June 2019 were selected as the research subjects. Inclusion criteria: ① Those who meet the diagnostic criteria of PCOS in western medicine; ② Those who meet the diagnostic criteria of irregular menstruation, infertility, and amenorrhea in traditional Chinese medicine; ③ Those who have not used any hormone drugs within 3 months; No antibiotics, probiotics or immunosuppressants were used within a week, no enteritis, acute and chronic gastrointestinal diseases, autoimmune diseases, etc., and no relevant operation history. ⑤Before recruitment, it was informed that biological samples should be collected before and after medication to evaluate the effect of TCM treatment. ⑥The selected volunteers had a detailed understanding of the sampling process and research purpose...

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PUM

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Abstract

The invention discloses a polycystic ovarian syndrome (PCOS) biomarker combination based on intestinal flora. The polycystic ovarian syndrome (PCOS) biomarker combination comprises one of the following microorganisms or a combination of the following microorganisms: Faecalibacteria, Actinomycetes, Butyricaceae, Clostridium butyricum and Streptococcus, and is applied to prognosis prediction of the polycystic ovarian syndrome (PCOS) through traditional Chinese medicine treatment.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to a marker of intestinal flora and its application in monitoring the treatment effect of polycystic ovary syndrome by traditional Chinese medicine. Background technique [0002] Polycystic ovary syndrome (PCOS) is a heterogeneous endocrine disease characterized by excessive secretion of luteinizing hormone and insufficient secretion of follicle-stimulating hormone in the anterior pituitary gland, hyperinsulinemia and insulin resistance, and hypersecretion of androgen . PCOS is the main cause of infertility, and it is also the focus of research on female reproductive disorders. The etiology of PCOS is still unclear, which limits the development of treatment methods. [0003] Recent studies have found that PCOS is closely related to intestinal flora. The results show that there are differences between the intestinal flora of PCOS patients and healthy controls. Compa...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/6883C12Q1/6869G16B20/30G16B40/00
CPCC12Q1/6869C12Q1/6883C12Q2600/118G16B20/30G16B40/00C12Q2531/113C12Q2535/122
Inventor 徐建华汪湾刘冬冬
Owner GUANGDONG HOSPITAL OF TRADITIONAL CHINESE MEDICINE
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