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Method for directly producing n-valeryl chloride and preparation method

A n-valeryl chloride, direct technology, applied in the field of direct production of n-valeryl chloride, can solve the problems of low efficiency of raw material processing and reaction, high energy consumption of production equipment operation, increase of production cost of n-valeryl chloride, etc., and achieve reduction of raw material use cost and The effect of energy consumption of processing equipment operation, reduction of production costs and environmental pollution, and improvement of comprehensive utilization of resources

Inactive Publication Date: 2021-06-11
河南佰研生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] N-valeryl chloride has a very wide application market in the production and preparation of medicines, and the amount of use is huge. At present, in the actual production process of n-valeryl chloride, traditional production and preparation processes are used, such as the "pharmaceutical grade positive Although it can meet the needs of the production and preparation of n-valeryl chloride, the production process is complicated, the production is difficult, the raw material processing reaction operation efficiency is low, and the reaction stability is poor, which seriously affects the production efficiency of n-valeryl chloride products. and product quality, and also lead to the production operation when utilizing traditional technology to prepare n-valeryl chloride, the energy consumption of production equipment operation is large, and the utilization rate of raw materials is low, which further increases the production cost of n-valeryl chloride

Method used

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  • Method for directly producing n-valeryl chloride and preparation method

Examples

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Effect test

Embodiment 1

[0022] A method for directly producing n-valeryl chloride, comprising the following steps:

[0023] S1, mother liquor configuration, first select n-valeric acid with a water content of wei 20%, and add the selected n-valeric acid to the reactor, then reduce the pressure in the reactor to 0.02MPa, and after completing the air pressure adjustment, turn the reactor The internal temperature is raised to 45°C at a uniform speed within 120 seconds, and kept warm for 5 minutes;

[0024] S2, mix phosphorus trichloride, after completing step S1, adjust the temperature of n-valeric acid in the reactor to 45°C while keeping the pressure in the reactor constant, and then drop it into the n-valeric acid in the reactor at a constant speed within 10 minutes Add phosphorus trichloride, and when the phosphorus trichloride is added dropwise, the temperature of the n-valeric acid drops by no more than 1°C, and during the dropwise addition of the phosphorus trichloride, the mixed solution in the ...

Embodiment 2

[0034] A method for directly producing n-valeryl chloride, comprising the following steps:

[0035] S1, mother liquor configuration, firstly select n-valeric acid with a water content of 0, and add the selected n-valeric acid into the reactor, then reduce the air pressure in the reactor to 0.05MPa, and reduce the temperature in the reactor after completing the air pressure adjustment Raise the temperature to 40°C at a uniform speed within 30 seconds, and keep it warm for 3 minutes;

[0036] S2, mix phosphorus trichloride, after completing step S1, adjust the temperature of n-valeric acid in the reactor to 48°C while keeping the pressure in the reactor constant, and then drop it into the n-valeric acid in the reactor at a constant speed within 30 minutes Add phosphorus trichloride, and when the phosphorus trichloride is added dropwise, the temperature of the n-valeric acid drops by no more than 1°C, and during the dropwise addition of the phosphorus trichloride, the mixed solut...

Embodiment 3

[0045] A method for directly producing n-valeryl chloride, comprising the following steps:

[0046] S1, mother liquor configuration, first select the n-valeric acid with a water content of 10%, and add the selected n-valeric acid into the reactor, then reduce the air pressure in the reactor to 0.03MPa, and after the air pressure adjustment is completed, the reactor The internal temperature is raised to 43°C at a constant speed within 100 seconds, and kept for 4 minutes;

[0047] S2, mix phosphorus trichloride, after completing step S1, adjust the temperature of n-valeric acid in the reactor to 46°C while keeping the pressure in the reactor constant, and then drop it into the n-valeric acid in the reactor at a constant speed within 15 minutes Add phosphorus trichloride, and when the phosphorus trichloride is added dropwise, the temperature of the n-valeric acid drops by no more than 1°C, and during the dropwise addition of the phosphorus trichloride, the mixed solution in the r...

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Abstract

The invention provides a method for directly producing n-valeryl chloride. The method comprises four steps of mother liquor preparation, phosphorus trichloride mixing, aging treatment and purification. Compared with the traditional production process of the n-valeryl chloride product, on one hand, the production process is effectively simplified, the production difficulty is reduced, and the production efficiency and the quality of the product can be effectively improved, and on the other hand, the raw material use cost and the operation energy consumption of processing operation equipment during production and preparation operation are effectively reduced; and the comprehensive utilization rate of resources can be effectively improved, and the quality and the additional value of n-valeryl chloride operation are greatly improved while the production cost and the environmental pollution are reduced.

Description

technical field [0001] The invention relates to a method for directly producing n-valeryl chloride and a preparation method, belonging to the technical field of biochemical industry. Background technique [0002] N-valeryl chloride has a very wide application market in the production and preparation of medicines, and the amount of use is huge. At present, in the actual production process of n-valeryl chloride, traditional production and preparation processes are used, such as the "pharmaceutical grade positive Although it can meet the needs of the production and preparation of n-valeryl chloride, the production process is complicated, the production is difficult, the raw material processing reaction operation efficiency is low, and the reaction stability is poor, which seriously affects the production efficiency of n-valeryl chloride products. and product quality, and also lead to the production operation when utilizing traditional technology to prepare n-valeryl chloride, t...

Claims

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Application Information

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IPC IPC(8): C07C51/60C07C53/42
CPCC07C51/60C07C53/42
Inventor 鞠超袁坤朋刘琼洋
Owner 河南佰研生物科技有限公司
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