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Spray compositions of chitosan for wound healing

A technology of composition and chitosan, which is applied in the direction of drug delivery, aerosol delivery, medical preparations of non-active ingredients, etc., can solve the problems of poor adhesion of wounds, inconvenient storage of large areas, large use area, etc.

Pending Publication Date: 2021-06-11
SHILPA MEDICARE LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The chitosan dressing is in the form of a sponge, which has a large area of ​​use on the wound surface of the body part, has poor adhesion to the wound, and requires a large area for storage and is not convenient for storage

Method used

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  • Spray compositions of chitosan for wound healing
  • Spray compositions of chitosan for wound healing
  • Spray compositions of chitosan for wound healing

Examples

Experimental program
Comparison scheme
Effect test

example 1-3

[0088] The preparation method of example 1-3

[0089] a. Collect 70% of the batch of water for injection into a suitable manufacturing container.

[0090] b. Add and disperse chitosan in step a.

[0091] c. Slowly add the required amount of 1 molar lactic acid until the chitosan is completely dissolved.

[0092] d. Make up volume to 100% batch with water for injection

[0093] e. The solution was filtered through 0.2μ and cooled to below 5°C.

[0094] f. Carbonate the solution and immediately fill into containers and close.

[0095] NOTE: If filled non-sterile, the product should be sterilized by gamma irradiation or other suitable sterilization method.

example 4-6

[0096] The preparation method of example 4-6

[0097] a. Collect 70% of the batch of water for injection into a suitable manufacturing container.

[0098] b. Add and disperse chitosan in step a.

[0099] c. Slowly add the required amount of 1 molar lactic acid until the chitosan is completely dissolved.

[0100] d. Add the portioned amount of glycerin to step c.

[0101] e. Make up volume to 100% batch with water for injection.

[0102] f. The solution was filtered through 0.2μ and cooled to below 5°C.

[0103] g. Carbonate the solution and immediately fill into containers and close.

[0104] NOTE: If filled non-sterile, the product should be sterilized by gamma irradiation or other suitable sterilization method.

example 7

[0105] Example 7: Excision Wound Healing Study Protocol

[0106] Anesthetize the rat with ketamine (30 mg / kg, ip) and mark about 500 mm with a standard ring on the back of the rat 2 area. The marked full-thickness skin is then carefully excised. Treatment started on day 1 and continued until day 22. Wounds were traced on OHP sheets, calculated on graph paper by superimposition on the day of wounding and at subsequent intervals of 4 days until day 12, and every other day thereafter until healing.

[0107] Changes in the wound area were measured regularly, and the wound contraction rate was calculated at the end of the study. The results are shown in Table 1 and figure 1 mentioned.

[0108] Table 1

[0109] Excision wound area - % inhibition:

[0110]

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Abstract

The present invention relates to topical spray compositions comprising chitosan and the method for preparation thereof. The topical spray compositions comprising chitosan are used for the treating burn wounds, wounds resulting from chemical burns, wounds from physical trauma, neuropathic ulcers, pressure sores, diabetic ulcers. Further, the spray compositions composition is used for treating gynaecological diseases, urogenital infections (vaginal bacteriosis, urinary tract infection and vaginitis) with good effect, safe, natural, and good biocompatibility by restoring and / or maintaining the pH of vagina. More specifically the present invention relates to topical spray compositions comprising chitosan and carbonic acid and the method for preparation thereof.

Description

technical field [0001] The present invention relates to topical spray compositions comprising chitosan for the treatment of wound healing and methods for their preparation. Further, the present invention relates to a topical spray composition for treating gynecological diseases, genitourinary tract infections (vaginal bacteriosis, urinary tract infection and vaginitis) by restoring and / or maintaining the pH of the vagina, which is effective, safe, natural and has Good biocompatibility. More specifically, the present invention discloses topical spray compositions comprising chitosan and carbonic acid. More specifically, the present invention discloses a spray composition comprising chitosan, lactic acid, carbonic acid and water stored in an autoclavable container bottle with a nozzle in can mode or stored in an autoclavable bag valve ( Bag-On-Valve, BOV) aerosol distribution system. Most particularly, the present invention discloses a topical spray composition comprising chi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/722A61K9/12
CPCA61K31/722A61K9/12A61K31/265A61K9/7015A61K9/0014A61K9/0034A61K47/36A61K47/12A61K2300/00A61K31/191
Inventor P·纳拉辛亚帕K·K·凯鲁库里V·V·K·乔希P·希瓦库马尔S·雷迪
Owner SHILPA MEDICARE LTD
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