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Long-acting external preparation containing disophenolum and preparation method and application thereof

An external preparation, the technology of iodonitrophen, which is applied in the field of long-acting external preparations to prevent or treat animal parasitic infections, can solve the problems of short duration of drug efficacy, need for repeated administration, and large dosage, so as to achieve enhanced anti-parasitic Insect effect, reduce animal irritation, reduce the effect of dosage

Active Publication Date: 2021-06-18
沈阳伟嘉生物技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this external transdermal preparation still cannot fully meet the needs of veterinary drug applications, because it still has problems such as large dosage, short duration of drug curative effect, and the need for repeated administration.

Method used

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  • Long-acting external preparation containing disophenolum and preparation method and application thereof
  • Long-acting external preparation containing disophenolum and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Embodiment 1: the preparation of the solution comprising iodonitrophenol

[0046] Formula 1 (the preferred formula of the present invention): iodonol 10g, eugenol 2g, ethyl acetate 10g, propylene glycol 15g, N,N-diethyl-3-methylbenzamide 2g, tert-butyl p-hydroxyanisole 1g, appropriate amount of ethanol, up to 100g.

[0047] Formula 2 (control without eugenol): iodonol 10g, ethyl acetate 10g, propylene glycol 15g, N,N-diethyl-3-methylbenzamide 2g, tert-butyl p-hydroxyanisole 1g, ethanol Appropriate amount, up to 100g.

[0048] Formula 3 (control without iodonitrophenol): eugenol 2g, ethyl acetate 10g, propylene glycol 15g, N,N-diethyl-3-methylbenzamide 2g, tert-butyl p-hydroxyanisole 1g, ethanol Appropriate amount, up to 100g.

[0049] Formula 4 (eugenol high-dose control): iodonol 10g, eugenol 10g, ethyl acetate 10g, propylene glycol 15g, N,N-diethyl-3-methylbenzamide 2g, tert-butyl p-hydroxy anise 1g of ether, appropriate amount of ethanol, up to 100g.

[0050] Fo...

Embodiment 2

[0052] Embodiment 2: the preparation of the ointment that comprises iodonitrophenol

[0053] Formula 1 (the preferred formula of the present invention): 10 g of iodonol, 2 g of eugenol, 20 g of glyceryl monostearate, 15 g of cetyl alcohol, 1 g of tert-butyl p-hydroxyanisole, 15 g of glycerol, 15 g of propylene glycol, appropriate amount of distilled water, to 100g.

[0054] Formula 2 (control without eugenol): 10 g of iodonol, 20 g of glyceryl monostearate, 15 g of cetyl alcohol, 1 g of tert-butyl p-hydroxyanisole, 15 g of glycerin, 15 g of propylene glycol, and appropriate amount of distilled water to 100 g.

[0055] Formula 3 (control without iodinol): 2 g of eugenol, 20 g of glyceryl monostearate, 15 g of cetyl alcohol, 1 g of tert-butyl p-hydroxyanisole, 15 g of glycerin, 15 g of propylene glycol, and appropriate amount of distilled water to 100 g.

[0056] Formula 4 (eugenol high dose control): iodonol 10g, eugenol 10g, glyceryl monostearate 20g, cetyl alcohol 15g, tert-...

Embodiment 3

[0059] Embodiment 3: the preparation of the cream that comprises iodonitrophenol

[0060] Formula 1 (the preferred formula of the present invention): iodonol 10g, eugenol 2g, sodium lauryl sulfate 1g, tert-butyl p-hydroxyanisole 1g, stearic acid 15g, glyceryl monostearate 15g, vaseline 5g , 5g of liquid paraffin, 2g of N,N-diethyl-3-methylbenzamide, 15g of glycerin, and an appropriate amount of distilled water to 100g.

[0061] Formula 2 (control without eugenol): 10 g of iodonol, 1 g of sodium lauryl sulfate, 1 g of tert-butyl p-hydroxyanisole, 15 g of stearic acid, 15 g of glyceryl monostearate, 5 g of petrolatum, liquid paraffin 5g, 2g of N,N-diethyl-3-methylbenzamide, 15g of glycerin, appropriate amount of distilled water, up to 100g.

[0062] Formula 3 (control without iodonitrophenol): eugenol 2g, sodium lauryl sulfate 1g, tert-butyl p-hydroxyanisole 1g, stearic acid 15g, glyceryl monostearate 15g, petrolatum 5g, liquid paraffin 5g, 2g of N,N-diethyl-3-methylbenzamide,...

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Abstract

The invention provides a long-acting external preparation for preventing or treating animal parasite infection and a preparation method and application thereof. The long-acting external preparation is prepared from the following components in percentage by weight: 5%-10% of disophenolum, 1%-5% of eugenol and an excipient which is acceptable in veterinary medicine. According to the long-acting external preparation, the anti-parasitic effect of the disophenolum is remarkably enhanced, and the acting time of the disophenolum is prolonged. By adding the eugenol which is relatively low in toxicity and environmentally friendly, the dosage of the disophenolum can be reduced, and the dosage of the preservative is greatly reduced, so that the safety of the external preparation is improved. The long-acting preparation can reduce medication times, reduce stimulation to animals and save a large amount of manpower and material resources.

Description

technical field [0001] The invention belongs to the field of veterinary medicine. Specifically, it relates to a long-acting external preparation containing iodonitrophenol, its preparation method and its use in preventing or treating animal parasitic infection. Background technique [0002] Animals are easy to carry parasites inside and outside the body, and parasites will have a serious impact on the growth and production performance of animals. Parasites can cause slow animal growth, reduced performance, and affect the quality of animal products. In addition, it may lead to problems such as zoonotic diseases. [0003] Iodonitrophenol (Disophenol) is also known as diiodonitrophenol, and its chemical name is 2,6-diiodo-4-nitrophenol. Iodonitrophenol was synthesized for the first time in the early 20th century, and it was gradually discovered in the 1960s that it can be used to drive and kill parasites in and out of animals. Shenyang Veterinary Medicine Factory successful...

Claims

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Application Information

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IPC IPC(8): A61K31/085A61K31/06A61K9/06A61K9/08A61P33/14
CPCA61K31/085A61K31/06A61K9/0014A61K9/06A61K9/08A61K47/18A61K47/14A61K47/20A61P33/14A61K2300/00
Inventor 赵宝凯闫琰王晓宇
Owner 沈阳伟嘉生物技术有限公司