Unlock instant, AI-driven research and patent intelligence for your innovation.

A long-acting external preparation containing iodonitrophenol and its preparation method and application

An external preparation, the technology of iodonitrophenol, which is applied in the field of prevention or treatment of animal parasitic infection and long-acting external preparations, can solve the problems of short duration of drug efficacy, large dosage, and the need for repeated administration, so as to achieve enhanced anti-parasitic Insect effect, reduce the dosage, reduce the stimulation effect of animals

Active Publication Date: 2022-03-25
沈阳伟嘉生物技术有限公司
View PDF5 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this external transdermal preparation still cannot fully meet the needs of veterinary drug applications, because it still has problems such as large dosage, short duration of drug curative effect, and the need for repeated administration.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A long-acting external preparation containing iodonitrophenol and its preparation method and application
  • A long-acting external preparation containing iodonitrophenol and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Embodiment 1: the preparation of the solution comprising iodonitrophenol

[0046] Formula 1 (the preferred formula of the present invention): 10 g of iodonol, 2 g of eugenol, 10 g of ethyl acetate, 15 g of propylene glycol, 2 g of N,N-diethyl-3-methylbenzamide, tert-butyl 1 g of p-hydroxyanisole, appropriate amount of ethanol, up to 100 g.

[0047] Formula 2 (control without eugenol): 10 g iodonitrophenol, 10 g ethyl acetate, 15 g propylene glycol, 2 g N,N-diethyl-3-methylbenzamide, tert-butyl p-hydroxyanisole Ether 1 g, appropriate amount of ethanol, to 100 g.

[0048] Formula 3 (control without iodonitrophenol): eugenol 2 g, ethyl acetate 10 g, propylene glycol 15 g, N,N-diethyl-3-methylbenzamide 2 g, tert-butyl p-hydroxyanisole Ether 1 g, appropriate amount of ethanol, to 100 g.

[0049] Formula 4 (eugenol high-dose control): iodonol 10 g, eugenol 10 g, ethyl acetate 10 g, propylene glycol 15 g, N,N-diethyl-3-methylbenzamide 2 g, tert-butyl 1 g of p-hydroxyanisol...

Embodiment 2

[0052] Embodiment 2: the preparation of the ointment that comprises iodonitrophenol

[0053] Formula 1 (the preferred formula of the present invention): iodonol 10 g, eugenol 2 g, glyceryl monostearate 20 g, cetyl alcohol 15 g, tert-butyl p-hydroxyanisole 1 g, glycerin 15 g, propylene glycol 15 g, appropriate amount of distilled water, to 100 g.

[0054] Formula 2 (control without eugenol): 10 g of iodonol, 20 g of glyceryl monostearate, 15 g of cetyl alcohol, 1 g of tert-butyl p-hydroxyanisole, 15 g of glycerin, 15 g of propylene glycol, distilled water Appropriate amount, up to 100 g.

[0055] Formula 3 (control without iodonitrophenol): eugenol 2 g, glyceryl monostearate 20 g, cetyl alcohol 15 g, tert-butyl p-hydroxyanisole 1 g, glycerin 15 g, propylene glycol 15 g, distilled water Appropriate amount, up to 100 g.

[0056] Formula 4 (eugenol high-dose control): iodonol 10 g, eugenol 10 g, glyceryl monostearate 20 g, cetyl alcohol 15 g, tert-butyl p-hydroxyanisole 1 g, gl...

Embodiment 3

[0059] Embodiment 3: the preparation of the cream that comprises iodonitrophenol

[0060] Formula 1 (the preferred formula of the present invention): 10 g of iodonol, 2 g of eugenol, 1 g of sodium lauryl sulfate, 1 g of tert-butyl p-hydroxyanisole, 15 g of stearic acid, glycerol monostearate 15 g of ester, 5 g of petrolatum, 5 g of liquid paraffin, 2 g of N,N-diethyl-3-methylbenzamide, 15 g of glycerin, and appropriate amount of distilled water to 100 g.

[0061] Formula 2 (control without eugenol): 10 g iodonitrophenol, 1 g sodium lauryl sulfate, 1 g tert-butyl p-hydroxyanisole, 15 g stearic acid, 15 g glyceryl monostearate, 5 g of petrolatum, 5 g of liquid paraffin, 2 g of N,N-diethyl-3-methylbenzamide, 15 g of glycerin, and an appropriate amount of distilled water, up to 100 g.

[0062] Formula 3 (control without iodonitrophenol): eugenol 2 g, sodium lauryl sulfate 1 g, tert-butyl p-hydroxyanisole 1 g, stearic acid 15 g, glyceryl monostearate 15 g, petrolatum 5 g, 5 g of ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
concentrationaaaaaaaaaa
weightaaaaaaaaaa
Login to View More

Abstract

The invention provides a long-acting external preparation for preventing or treating animal parasitic infection, its preparation method and application. The long-acting external preparation comprises 5%-10% iodonol, 1%-5% eugenol and veterinary pharmaceutically acceptable excipients in weight percentage. The long-acting external preparation significantly enhances the antiparasitic effect of iodonitrophenol and prolongs the action time of iodonitrophenol. By adding eugenol which is less toxic and friendly to the environment, the dosage of iodonitrophenol can be reduced, and the dosage of preservatives can be greatly reduced, thereby increasing the safety of the external preparation. The long-acting preparation can reduce the frequency of administration, reduce stimulation to animals, and save a lot of manpower and material resources.

Description

technical field [0001] The invention belongs to the field of veterinary medicine. Specifically, it relates to a long-acting external preparation containing iodonitrophenol, its preparation method and its use in preventing or treating animal parasitic infection. Background technique [0002] Animals are easy to carry parasites inside and outside the body, and parasites will have a serious impact on the growth and production performance of animals. Parasites can cause slow animal growth, reduced performance, and affect the quality of animal products. In addition, it may lead to problems such as zoonotic diseases. [0003] Disophenol, also known as diiodonitrophenol, has a chemical name of 2, 6-diiodo-4-nitrophenol. Iodonitrophenol was synthesized for the first time in the early 20th century, and it was gradually discovered in the 1960s that it can be used to drive and kill parasites in and out of animals. Shenyang Veterinary Medicine Factory successfully imitated iodonitro...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/085A61K31/06A61K9/06A61K9/08A61P33/14
CPCA61K31/085A61K31/06A61K9/0014A61K9/06A61K9/08A61K47/18A61K47/14A61K47/20A61P33/14A61K2300/00
Inventor 赵宝凯闫琰王晓宇
Owner 沈阳伟嘉生物技术有限公司