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A technology of albendazol ivermectin powder and microcrystalline cellulose, which is applied in the field of veterinary anthelmintics, can solve the problem of reluctance to swallow drugs in animals, uneven mixing of ivermectin, and increased labor of breeders and other problems, to achieve the effect of eliminating toxic and side effects, increasing the range of anti-parasites, and reducing the number of medications
Inactive Publication Date: 2013-05-08
金河牧星(重庆)生物科技有限公司
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The above drugs need to be used in combination to completely drive away internal and external parasites. Repeated use of drugs not only wastes resources, but also increases the labor of the breeders
Moreover, the above-mentioned dosage forms are used for oral administration and mixed feeding. Patients often have difficulty swallowing and are unwilling to take the medicine. However, because the dosage of ivermectin premix is very small, it often cannot be mixed evenly when used in mixed feed. accident of poisoning
[0006] In the prior art, there have also been reports of compounding albendazole and ivermectin into compound preparations, such as application number 200710150563.9 and application number 201010242809.7, but these preparations still have relatively low efficacy problems, and they are all dry powders used for mixing with feed, there is still the risk of poisoning accidents caused by uneven mixing of ivermectin in feed
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[0032] Step 1: Stir and mix the prescribed amount of ivermectin and sodium carboxymethylcellulose. After the powder is uniform, add sodium saccharin and mix again to obtain powder A, which is set aside;
[0033] Step 2: Take the prescribed amount of albendazole and sodium chloride and stir and mix. After the powder is uniform, add sodium citrate and mix evenly again to prepare B powder;
[0034] Step 3: Add the above B powder to A powder according to the same addition method and stir evenly, then add enough soluble starch and continue to stir and mix for 10 minutes. The albendazole ivermectin powder of off-white powder is obtained.
[0042] 2: Preparation method: the same as the method described in Example 1.
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Abstract
The invention relates to an anthelmintic drug for livestock, and particularly relates to albendazole / ivermectin powder for livestock, which is convenient to use and remarkable in drug effect. Every 100g of albendazole / ivermectin powder comprises 5-15g of albendazole, 0.1-0.2g of ivermectin, 10-20g of sodium chloride, 5-10g of sodium citrate, 2-4g of sodium carboxymethyl cellulose, 2-4g of flavoring agent and the balance of other acceptable auxiliary material, wherein the other auxiliary material is soluble starch or microcrystalline cellulose. The drug provided by the invention is a dry suspension, can be proportionally added in a drinking fountain directly for use, and facilitates the all-round dosing in a large-size livestock farm; the drug avoids the toxic and side effect caused by uneven feed mixing and is more convenient to use; and the drug effect is remarkably enhanced, and the cost is obviously lowered in comparison with the prior art, thereby ensuring that the drug has wide application prospects.
Description
technical field [0001] The invention relates to a veterinary anthelmintic, and also relates to veterinary albendazole and ivermectin. Background technique [0002] Albendazole, a benzimidazole anti-helminth drug, has broad-spectrum anthelmintic activity, and has a strong killing effect on nematodes, tapeworms, and trematodes in livestock and poultry. Its mechanism of action is to bind to tubulin in worms and prevent it from multimerizing with α-tubulin to form microtubules, thereby affecting cell reproduction processes such as mitosis, protein assembly and energy metabolism in worms, and inhibiting The purpose of parasite growth and reproduction. [0003] Ivermectin has a good killing effect on internal and external parasites, especially arthropod insects and internal nematodes, and is mainly used to expel gastrointestinal nematodes, lung nematodes and external parasites in pigs and other animals. Its deworming mechanism is to promote the release of γ-aminobutyric acid (GA...
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