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Active peptide with effect of preventing chronic alcoholic liver injury

A technology of alcoholic liver injury and active peptides, applied in the field of active peptides that can prevent chronic alcoholic liver injury, to achieve the effect of preventing chronic alcoholic liver injury

Active Publication Date: 2021-06-18
JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to provide an active peptide capable of preventing chronic alcoholic liver injury, so as to solve the problem of developing liver-protecting products with clear biologically active ingredients

Method used

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  • Active peptide with effect of preventing chronic alcoholic liver injury
  • Active peptide with effect of preventing chronic alcoholic liver injury
  • Active peptide with effect of preventing chronic alcoholic liver injury

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Example 1: Preparation, separation, purification and identification of active peptides

[0025] (1) crushing commercially available soybean meal through a pulverizer, and sieving through a 60-mesh sieve;

[0026] (2) Prepare the solution according to the substrate concentration of 9%, stir it evenly and then perform ultrasonic treatment, the ultrasonic power is 300w, and the ultrasonic time is 9min;

[0027] (3) After the ultrasound is finished, place the solution in a boiling water bath for protein denaturation for 10 minutes;

[0028] (4) Lower the temperature of the denatured solution to 50°C, adjust the pH to 8.0 with acid and alkali solution, and then add alkaline protease to start enzymolysis, the amount of enzyme added is 7000U / g, and the enzymolysis time is 3h;

[0029] (5) After the enzymolysis is finished, place the solution in a boiling water bath to kill the enzyme for 10 minutes;

[0030] (6) The solution after inactivating the enzyme was lowered to room ...

Embodiment 2

[0036] Example 2: The active peptide GTYW has the effect of preventing chronic alcoholic liver injury

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Abstract

The invention discloses an active peptide with an effect of preventing chronic alcoholic liver injury. The amino acid sequence of the active peptide is Gly-Thr-Tyr-Trp (GTYW). According to the invention, in the chronic alcoholic liver injury animal model experiment, the active peptide can significantly reduce the mouse serum AST and ALT activity and the liver / serum TG content and significantly increase the mouse liver AST and ALT activity, and the liver tissue injury caused by ethanol is gradually improved through the pathological section, so that it is indicated that the GTYW has the effect of preventing the chronic alcoholic liver injury. According to the active peptide, not only can the economic added value of soybean meal be increased, but also a new thought for development and utilization of liver protection products is provided.

Description

technical field [0001] The invention belongs to the field of bioactive peptides, in particular to an active peptide capable of preventing chronic alcoholic liver injury. Background technique [0002] As a drink, wine is essential no matter in daily diet or in social occasions. Moderate drinking can not only make people happy, relieve fatigue, relieve worries and sorrows, but also promote blood flow, gastrointestinal digestion, etc. However, excessive alcohol consumption, especially long-term chronic alcohol consumption, can cause damage to various organ systems, such as liver damage. In recent years, the incidence of alcoholic liver disease has been increasing year by year. Alcohol has become the second leading cause of liver damage after hepatitis virus, seriously endangering human life and health. Therefore, the development of safe and effective liver protection products has important social significance and practical value. [0003] Most of the liver-protecting product...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K5/103C07K1/34C12P21/06A61K38/07A61P1/16A61P3/06A23L33/18
CPCC07K5/1008C12P21/06A61P1/16A61P3/06A23L33/18A61K38/00A23V2002/00A23V2200/334A23V2250/55
Inventor 潘风光蔡转章刘静波张婷
Owner JILIN UNIV
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