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Livestock feed additive

A technology of feed additives and feed, applied in animal husbandry, animal feed, animal feed, etc., can solve problems such as doubtful results

Pending Publication Date: 2021-06-29
DELACON BIOTECHN GMBH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the results of this study are questionable because the administration of hesperidin down-regulated the expression of heat shock protein 70
There is no research report on the protective effect of citrus flavonoids, especially naringin, on intestinal barrier function under heat stress conditions.

Method used

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  • Livestock feed additive
  • Livestock feed additive
  • Livestock feed additive

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0182] Exemplary compositions of feed additive compositions described herein for use in breeding ruminants (eg, cattle) are described in Example 1.

[0183] Further examples of analytical methods for the determination of the active substances 1,8-cineole, naringin and betaine in feed additive compositions are also provided herein.

[0184] Also provided herein are further examples of in vivo and in vitro testing of the effects of feed additives such as

[0185] i. In vivo assay of the lifespan-prolonging effect of exposure to heat stress in C. elegans,

[0186] ii. In vitro test of CaCo2 cell heat shock protein induction;

[0187] iii. Intestinal barrier function was tested in vitro by transepithelial electrical resistance (TEER) of migrating CaCo2 cells;

[0188] iv. In vivo verification of the beneficial effects of naringin on broiler growth performance under heat stress and evaluation of beneficial dose levels;

[0189] v. In vivo verification of beneficial effects of na...

Embodiment

[0193] Example 1: Exemplary feed called "Novel Feed Additive to Support Animal Welfare under Heat Stress Conditions" additive

[0194] An exemplary composition comprises the following ingredients mixed into a dry flowable mixture. Given that the oil fraction is a specific Lamiaceae oil or a mixture of Lamiaceae oils (e.g. oregano oil and / or rosemary oil and / or thyme oil), the oil fraction is standardized to a 1,8 cineole concentration , the flavonoid fraction was derived from citrus flavonoids and normalized to the naringin concentration, and the betaine fraction was derived from beet root powder and was normalized to the betaine concentration.

[0195] Table 1: Formulation I; Novel feed additive formulation composition for poultry (broilers, layers, turkeys) and pigs

[0196]

[0197] Exemplary feed additive formulation I contained 1.50% 1,8-cineole (w / w); the effective ratio was 0.65:1 (w / w 1,8-cineole:naringin).

[0198] Table 2: Formulation II; Novel feed additive...

Embodiment 2

[0214] Embodiment 2: Description of analytical method and test method:

[0215] Explanation of the evidence of analysis of the active substance

[0216] 1.1,8 Cineole (1,8Cineole or 1,8-Cin) (compound "A")

[0217] 2. Naringin (Naringin or Nar) (compound "B")

[0218] 3. Betalain (or Betal) (compound "C")

[0219] Description of test methods and results

[0220] 4. Test I: Life extension test of Caenorhabditis elegans

[0221] 5. Test II: In vitro test of heat shock protein induction in CaCo2 cells

[0222] 6. Experiment III: In vitro test of intestinal barrier function by migrating CaCo2 cells transepithelial electrical resistance (TEER)

[0223] 7. Experiment IV: In vivo verification of beneficial effects of naringin (compound "A") on growth performance of broiler chickens under heat stress and evaluation of optimal dosage levels

[0224] 8. Test V: In vivo verification of the effects of naringin (compound "B") combined with different concentrations of 1,8-cineole (c...

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Abstract

A livestock feed additive comprising 1,8 cineole, and at least one of naringin or betalain, and a feed product comprising the same.

Description

technical field [0001] The present invention relates to livestock feed additives and corresponding food products which assist in the breeding of animals under heat stress. Background technique [0002] Veterinary additives are commonly used to increase the nutritional value of animal diets. Such additives include enzymes and certain phytogenics, among others. Plant-derived (plant-derived, natural, botanical) feed additives are compositions that are intimately mixed with specific plant-based raw materials and plant-derived and / or mineral-based carriers. For this, essential and / or vegetable oils are used, as well as a large number of highly active herbs and spices with specific aromatic and appetizing properties. [0003] Products of plant origin are used as animal husbandry additives, developed to improve the quality of animals, for example to improve the health of poultry and / or to produce profitable poultry products, especially for fattening and egg production. Plant-der...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23K50/00A23K50/10A23K50/75A23K50/30A61K31/00A23K10/30
CPCA23K10/30A23K20/121A23K50/10A23K50/30A23K50/75A23K20/137A23K20/158A23K20/111A61K9/0056A61K31/05A61K31/352A61K31/7048A61K36/21A61K36/53A61K36/752A61K45/06
Inventor A·S·米勒
Owner DELACON BIOTECHN GMBH