Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Application of heparin analogue in preparation of medicine for treating or preventing acute pancreatitis

A technology for acute pancreatitis and analogues, which is applied in the application field of heparin analogues in the preparation of medicines for the treatment or prevention of acute pancreatitis, can solve problems such as massive bleeding, and achieve the purpose of removing anticoagulation, maintaining effectiveness and improving safety. Effect

Active Publication Date: 2021-07-09
JIANGNAN UNIV
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, because low molecular weight heparin has the function of anticoagulation, it often has the risk of massive bleeding when used clinically.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of heparin analogue in preparation of medicine for treating or preventing acute pancreatitis
  • Application of heparin analogue in preparation of medicine for treating or preventing acute pancreatitis
  • Application of heparin analogue in preparation of medicine for treating or preventing acute pancreatitis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0036] (1) Preparation of non-anticoagulant heparin by derivatization method

[0037] 1. Preparation of Heparin Pyridinium Salt

[0038] Take 40mL of cation exchange resin and wash it three times with deionized water, weigh 10g of refined heparin sodium and dissolve it in 80mL of deionized water, add it to the resin after pre-cooling at 4°C, shake at 210rpm for 40min on a shaker at 4°C. The supernatant was taken, placed on ice, and the resin was washed with water (three times) until the pH was neutral. Finally, the total volume was approximately 500 mL, and about 6 mL of pyridine was added on ice to adjust the pH to neutral, and then freeze-dried to obtain heparin pyridine salt.

[0039] 2. Preparation of Partially Desulfated Heparin

[0040] Weigh 2g of heparin pyridine salt and add 200mL of anhydrous pyridine, fill with N2 and stir to dissolve, add 20mL of MTSTFA and fill with nitrogen, heat in an oil bath at 110°C for 2.5h, and then start rotary evaporation. After rotary...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides application of a heparin analogue in preparation of a medicine for treating or preventing acute pancreatitis, and belongs to the technical field of biological medicine materials. The heparin analogue is 6-desulfated heparin or N,O-acetylated heparin, can effectively remove an anticoagulant effect, and retains an anti-pancreatitis effect in an integral animal experiment, so that the safety is greatly improved, and meanwhile, the effectiveness of a medicine is kept.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to the application of a heparin analogue in the preparation of medicines for treating or preventing acute pancreatitis. Background technique [0002] Acute pancreatitis (AP) is a common critical disease of the digestive system, which is caused by the autodigestion of pancreatic tissue after the activation of pancreatic enzymes in the pancreas. Syndrome, seriously endangering the life of the patient. In recent years, the incidence of acute pancreatitis in my country has been increasing year by year, and the overall mortality rate of acute pancreatitis is as high as 5%. Studies have shown that the pathogenesis of acute pancreatitis mainly includes obesity, hyperlipidemia, inflammatory response caused by excessive activation of leukocytes, pancreatic microcirculation disturbance, and inflammatory response caused by necrosis of pancreatic alveolar cells. At present, the c...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/727A61P1/18
CPCA61K31/727A61P1/18
Inventor 闫昳姝杨晶汤旭娇戴雨桐柯雪张娜
Owner JIANGNAN UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com